Pamela J B Brown
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Explore the profile of Pamela J B Brown including associated specialties, affiliations and a list of published articles.
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40
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787
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Recent Articles
1.
Aliashkevich A, Guest T, Alvarez L, Gilmore M, Rea D, Amstutz J, et al.
PLoS Genet
. 2024 Oct;
20(10):e1011449.
PMID: 39432536
Peptidoglycan (PG), a mesh-like structure which is the primary component of the bacterial cell wall, is crucial to maintain cell integrity and shape. While most bacteria rely on penicillin binding...
2.
Payne I, Aubry B, Barrows J, Brown P, Goley E
J Bacteriol
. 2024 Sep;
206(10):e0022524.
PMID: 39291979
In almost all bacteria, the tubulin-like GTPase FtsZ polymerizes to form a "Z-ring" that marks the site of division. FtsZ recruits other proteins, collectively known as the divisome, that together...
3.
Gilmore M, Yadav A, Espaillat A, Gust A, Williams M, Brown P, et al.
J Biol Chem
. 2023 Dec;
300(2):105611.
PMID: 38159848
During growth, bacteria remodel and recycle their peptidoglycan (PG). A key family of PG-degrading enzymes is the lytic transglycosylases, which produce anhydromuropeptides, a modification that caps the PG chains and...
4.
Santiago-Collazo G, Brown P, Randich A
Trends Microbiol
. 2023 Sep;
32(3):231-240.
PMID: 37741788
The bacterial divisome is a complex nanomachine that drives cell division and separation. The essentiality of these processes leads to the assumption that proteins with core roles will be strictly...
5.
Brown P, Chang J, Fuqua C
J Bacteriol
. 2023 Mar;
205(4):e0000523.
PMID: 36892285
Agrobacterium tumefaciens incites the formation of readily visible macroscopic structures known as crown galls on plant tissues that it infects. Records from biologists as early as the 17th century noted...
6.
Williams M, Bouchier J, Mason A, Brown P
PLoS Genet
. 2022 Dec;
18(12):e1010274.
PMID: 36480495
A core component of nearly all bacteria, the cell wall is an ideal target for broad spectrum antibiotics. Many bacteria have evolved strategies to sense and respond to antibiotics targeting...
7.
Figueroa-Cuilan W, Howell M, Richards C, Randich A, Yadav A, Cava F, et al.
Appl Environ Microbiol
. 2022 May;
88(12):e0033322.
PMID: 35638841
The remarkable ability of Agrobacterium tumefaciens to transfer DNA to plant cells has allowed the generation of important transgenic crops. One challenge of A. tumefaciens-mediated transformation is eliminating the bacteria...
8.
Williams M, Aliashkevich A, Krol E, Kuru E, Bouchier J, Rittichier J, et al.
mBio
. 2021 Sep;
12(5):e0234621.
PMID: 34544272
Members of the are polarly growing bacteria that lack homologs of the canonical Rod complex. To investigate the mechanisms underlying polar cell wall synthesis, we systematically probed the function of...
9.
Figueroa-Cuilan W, Randich A, Dunn C, Santiago-Collazo G, Yowell A, Brown P
Front Microbiol
. 2021 Sep;
12:729307.
PMID: 34489918
LytM-domain containing proteins are LAS peptidases (lysostaphin-type enzymes, D-Ala-D-Ala metallopeptidases, and sonic hedgehog) and are known to play diverse roles throughout the bacterial cell cycle through direct or indirect hydrolysis...
10.
Aliashkevich A, Howell M, Brown P, Cava F
Environ Microbiol
. 2021 Apr;
23(10):5823-5836.
PMID: 33830599
The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for maintenance of cell shape and survival. Many bacteria alter their PG chemistry as a strategy...