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Pallavi P Gopal

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Articles 24
Citations 309
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Recent Articles
1.
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, et al.
Sci Transl Med . 2024 Oct; 16(771):eabo1997. PMID: 39475571
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence suggests that pathogenesis may be in part mediated by inflammatory processes, the molecular and cellular architectures of which are...
2.
Wijegunawardana D, Nayak A, Vishal S, Venkatesh N, Gopal P
Dev Cell . 2024 Oct; 60(2):253-269.e5. PMID: 39419034
Altered RNA metabolism and misregulation of transactive response DNA-binding protein of 43 kDa (TDP-43), an essential RNA-binding protein (RBP), define amyotrophic lateral sclerosis (ALS). Intermediate-length polyglutamine (polyQ) expansions of Ataxin-2,...
3.
Salaikumaran M, Gopal P
ACS Chem Neurosci . 2024 Mar; 15(6):1096-1109. PMID: 38466778
TDP-43, an essential RNA/DNA-binding protein, is central to the pathology of neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia. Pathological mislocalization and aggregation of TDP-43 disrupt RNA splicing,...
4.
Salaikumaran M, Gopal P
bioRxiv . 2023 Nov; PMID: 37961353
TDP-43, an essential RNA/DNA-binding protein, is central to the pathology of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Pathological mislocalization and aggregation of TDP-43 disrupts RNA splicing,...
5.
Naskar A, Nayak A, Salaikumaran M, Vishal S, Gopal P
Front Mol Neurosci . 2023 Sep; 16:1242925. PMID: 37720552
Liquid-liquid phase separation results in the formation of dynamic biomolecular condensates, also known as membrane-less organelles, that allow for the assembly of functional compartments and higher order structures within cells....
6.
Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, et al.
Neurooncol Adv . 2023 Jul; 5(1):vdad076. PMID: 37476329
Background: Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but the leading cause in pediatric patients and young adults. The variety and complexity...
7.
Zhang L, He C, Coffey S, Yin D, Hsu I, Su C, et al.
medRxiv . 2023 Mar; PMID: 36865305
Alzheimer's disease, the most common age-related neurodegenerative disease, is closely associated with both amyloid-ß plaque and neuroinflammation. Two thirds of Alzheimer's disease patients are females and they have a higher...
8.
Wijegunawardana D, Vishal S, Venkatesh N, Gopal P
bioRxiv . 2023 Feb; PMID: 36778347
Altered RNA metabolism is a common pathogenic mechanism linked to familial and sporadic Amyotrophic lateral sclerosis (ALS). ALS is characterized by mislocalization and aggregation of TDP-43, an RNA-binding protein (RBP)...
9.
Tabor J, Lei H, Morales-Valero S, OBrien J, Gopal P, Erson-Omay E, et al.
J Neurosurg Case Lessons . 2023 Jan; 5(4). PMID: 36692065
Background: Primary intracranial leiomyosarcomas (PILMSs) are extremely rare tumors arising from smooth muscle connective tissue. PILMSs have been shown to be associated with Epstein-Barr virus (EBV). Thus far, EBV-associated PILMS...
10.
Vishal S, Wijegunawardana D, Salaikumaran M, Gopal P
Front Cell Dev Biol . 2022 Jun; 10:876893. PMID: 35646935
Mutations in TDP-43, a RNA-binding protein with multiple functions in RNA metabolism, cause amyotrophic lateral sclerosis (ALS), but it is uncertain how defects in RNA biology trigger motor neuron degeneration....