Pablo Artigas
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Explore the profile of Pablo Artigas including associated specialties, affiliations and a list of published articles.
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35
Citations
483
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Recent Articles
1.
Nielsen H, Holm R, Sweazey R, Andersen J, Artigas P, Vilsen B
Biomolecules
. 2024 Jan;
14(1).
PMID: 38275764
Na,K-ATPase actively extrudes three cytoplasmic Na ions in exchange for two extracellular K ions for each ATP hydrolyzed. The atomic structure with bound Na identifies three Na sites, named I,...
2.
Artigas P, Meyer D, Young V, Spontarelli K, Eastman J, Strandquist E, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(52):e2313999120.
PMID: 38079564
Brine shrimp () are the only animals to thrive at sodium concentrations above 4 M. Salt excretion is powered by the Na,K-ATPase (NKA), a heterodimeric (αβ) pump that usually exports...
3.
Spontarelli K, Young V, Sweazey R, Padro A, Lee J, Bueso T, et al.
Biochim Biophys Acta Mol Cell Res
. 2023 Sep;
1871(1):119572.
PMID: 37659504
Heterozygous germline variants in ATP1A1, the gene encoding the α1 subunit of the Na/K-ATPase (NKA), have been linked to diseases including primary hyperaldosteronism and the peripheral neuropathy Charcot-Marie-Tooth disease (CMT)....
4.
Abe K, Nishizawa T, Artigas P
Biochim Biophys Acta Mol Cell Res
. 2023 Jul;
1870(7):119543.
PMID: 37482134
The Na,K-ATPase (NKA) and non-gastric H,K- ATPase (ngHKA) share ~65 % sequence identity, and nearly identical catalytic cycles. These pumps alternate between inward-facing (E1) and outward-facing (E2) conformations and differ...
5.
Spontarelli K, Young V, Sweazey R, Padro A, Lee J, Bueso T, et al.
bioRxiv
. 2023 Apr;
PMID: 37090550
Heterozygous germline variants in , the gene encoding the α1 subunit of the Na /K -ATPase (NKA), have been linked to diseases including primary hyperaldosteronism and the peripheral neuropathy Charcot-Marie-Tooth...
6.
Cinarli Yuksel F, Nicolaou P, Spontarelli K, Dohrn M, Rebelo A, Koutsou P, et al.
J Neurol
. 2023 Feb;
270(5):2576-2590.
PMID: 36738336
Background: Charcot-Marie-Tooth disease (CMT) is a genetically and clinically heterogeneous group of inherited neuropathies. Monoallelic pathogenic variants in ATP1A1 were associated with axonal and intermediate CMT. ATP1A1 encodes for the...
7.
Young V, Nakanishi H, Meyer D, Nishizawa T, Oshima A, Artigas P, et al.
Nat Commun
. 2022 Sep;
13(1):5270.
PMID: 36085139
Ion-transport mechanisms evolve by changing ion-selectivity, such as switching from Na to H selectivity in secondary-active transporters or P-type-ATPases. Here we study primary-active transport via P-type ATPases using functional and...
8.
Spontarelli K, Infield D, Nielsen H, Holm R, Young V, Galpin J, et al.
J Gen Physiol
. 2022 Jun;
154(7).
PMID: 35657726
The essential transmembrane Na+ and K+ gradients in animal cells are established by the Na+/K+ pump, a P-type ATPase that exports three Na+ and imports two K+ per ATP hydrolyzed....
9.
Biondo E, Spontarelli K, Ababioh G, Mendez L, Artigas P
Am J Physiol Cell Physiol
. 2021 Jul;
321(2):C394-C408.
PMID: 34232746
Human cell survival requires function of the Na/K pump; the heteromeric protein that hydrolyzes ATP to extrude Na and import K across the plasmalemma, thereby building and maintaining these ions'...
10.
Yap J, Seflova J, Sweazey R, Artigas P, Robia S
J Gen Physiol
. 2021 Mar;
153(4).
PMID: 33688925
The sodium/potassium-ATPase (NKA) is the enzyme that establishes gradients of sodium and potassium across the plasma membrane. NKA activity is tightly regulated for different physiological contexts through interactions with single-span...