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P W Schiller

Explore the profile of P W Schiller including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 157
Citations 944
Followers 0
Related Specialties
Biochemistry
Chemistry
Pharmacology
Top 10 Co-Authors
N N Chung
C Lemieux
T M Nguyen
B C Wilkes
G Weltrowska
M Goodman
R Schmidt
M Cantin
K A Carpenter
D F Mierke
Published In
Int J Pept Protein Res
J Med Chem
Biochem Biophys Res Commun
Biopolymers
J Pept Res
Affiliations
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Recent Articles
1.
Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats
Kotlinska J, Gibula-Bruzda E, Witkowska E, Chung N, Schiller P, Izdebski J
Peptides . 2012 Nov; 39:103-10. PMID: 23183627
The antinociceptive effects of analogs of deltorphins: cyclo(Nδ,Nδ-carbonyl-D-Orn2, Orn4)deltorphin (DEL-6) and deltorphin II N-(ureidoethyl)amide (DK-4) after intracerebroventricular (i.c.v.) administration were investigated in the tail-immersion test in rats. Morphine, the most...
2.
Deltorphin analogs restricted via a urea bridge: structure and opioid activity
Ciarkowski J, Zieleniak A, Rodziewicz-Motowidlo S, Rusak L, Chung N, Czaplewski C, et al.
Adv Exp Med Biol . 2009 Apr; 611:491-2. PMID: 19400279
No abstract available.
3.
Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold
Ballet S, Frycia A, Piron J, Chung N, Schiller P, Kosson P, et al.
J Pept Res . 2005 Oct; 66(5):222-30. PMID: 16218989
The synthesis of conformationally restricted dipeptidic moieties 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba)-Gly ([(4S)-amino-3-oxo-1,2,4,5-tetrahydro-1H-2-benzazepin-2-yl]-acetic acid) and 8-hydroxy-4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Hba)-D-Ala ([(4S)-amino-8-hydroxy-3-oxo-1,2,4,5-tetrahydro-benzo[c]azepin-2-yl]-propionic acid) was based on a synthetic strategy that uses an oxazolidinone as an N-acyliminium precursor....
4.
Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity
Kruszynski R, Fichna J, Do-Rego J, Chung N, Schiller P, Kosson P, et al.
J Pept Res . 2005 Aug; 66(3):125-31. PMID: 16083439
A series of position 4-substituted endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) analogs containing 3-(1-naphthyl)-alanine (1-Nal) or 3-(2-naphthyl)-alanine (2-Nal) in L- or D-configuration, was synthesized. The opioid activity profiles of these peptides were determined in...
5.
Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy
Schiller P, Berezowska I, Weltrowska G, Chen H, Lemieux C, Chung N
J Pept Res . 2005 May; 65(6):556-63. PMID: 15885115
The dermorphin-derived tetrapeptide H-Dmt-d-Arg-Phe-Lys-NH(2) (Dmt = 2',6'-dimethyltyrosine) ([Dmt(1)]DALDA) is a highly potent and selective mu-opioid agonist capable of crossing the blood-brain barrier and producing a potent, centrally mediated analgesic effect...
6.
Cyclic enkephalin analogs containing various para-substituted phenylalanine derivatives in place of Tyr1 are potent opioid agonists
Weltrowska G, Lemieux C, Chung N, Schiller P
J Pept Res . 2005 Feb; 65(1):36-41. PMID: 15686532
The cyclic enkephalin analog H-Tyr-c[D-Cys-Gly-Phe(pNO(2))-D-Cys]NH(2) is a highly potent opioid agonist with IC(50)s of 35 pm and 19 pm in the guinea-pig ileum (GPI) and mouse vas deferens (MVD) assays,...
7.
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors
Tryoen-Toth P, Decaillot F, Filliol D, Befort K, Lazarus L, Schiller P, et al.
J Pharmacol Exp Ther . 2004 Dec; 313(1):410-21. PMID: 15590769
The delta opioid receptor modulates nociceptive and emotional behaviors. This receptor has been shown to exhibit measurable spontaneous activity. Progress in understanding the biological relevance of this activity has been...
8.
The cardiovascular and renal effects of the potent and highly selective mu opioid agonist [Dmt1]DALDA
Gutkowska J, Mukaddam-Daher S, Jankowski M, Schiller P
J Cardiovasc Pharmacol . 2004 Nov; 44(6):651-8. PMID: 15550783
The cardiovascular and renal effects of a mu opioid agonist, [Dmt]DALDA, were studied in conscious Sprague-Dawley rats. During the first hour postinjection, [Dmt]DALDA (0.025-250 microg/rat, IV) evoked a dose-dependent diuresis....
9.
A chimeric opioid peptide with mixed mu agonist/delta antagonist properties
Weltrowska G, Lemieux C, Chung N, Schiller P
J Pept Res . 2004 Mar; 63(2):63-8. PMID: 15009527
There is evidence to indicate that opioid compounds with mixed mu agonist/delta antagonist properties are analgesics with low propensity to produce tolerance and physical dependence. A chimeric peptide containing the...
10.
A novel cis-peptide bond motif inducing beta-turn type VI. The synthesis of enkephalin analogues modified with 4-aminopyroglutamic acid
Kaczmarek K, Kaleta M, Chung N, Schiller P, Zabrocki J
Acta Biochim Pol . 2002 May; 48(4):1159-63. PMID: 11995985
A new pathway leading to a mixture of four isomers of 4-aminopyroglutamic acid is described. Michael type addition of Z-deltaAla-OMe to enolates prepared from acylaminomalonates, followed by hydrolysis and decarboxylation...