P W Hale Jr
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Explore the profile of P W Hale Jr including associated specialties, affiliations and a list of published articles.
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7
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19
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Recent Articles
1.
Hale Jr P, Poklis A
Toxicol Appl Pharmacol
. 1986 Oct;
86(1):44-55.
PMID: 3764935
The cardiotoxic potential of the phenothiazine neuroleptic thioridazine and five of its metabolites, including two stereoisomeric forms of thioridazine 5-sulfoxide (ring sulfoxide), was characterized in the isolated perfused rat heart....
2.
Hale Jr P, Poklis A
Eur J Drug Metab Pharmacokinet
. 1986 Oct;
11(4):283-9.
PMID: 3582423
The disposition and urinary elimination of thioridazine 5-sulfoxide (ring sulfoxide) following subacute administration of thioridazine was investigated in control and phenobarbital (Pb) induced rats. The ring sulfoxide exists as two...
3.
Hale Jr P, Melethil S, Poklis A
Eur J Drug Metab Pharmacokinet
. 1985 Oct;
10(4):333-41.
PMID: 3830721
The disposition and elimination of 2 stereoisomeric forms of thioridazine 5-sulfoxide (ring sulfoxide) were followed for 72 hr in male Sprague-Dawley rats following the administration of a single 40 mg/kg...
4.
Hale Jr P, Poklis A
J Anal Toxicol
. 1985 Sep;
9(5):197-201.
PMID: 4057956
Two diastereoisomeric pairs of thioridazine 5-sulfoxide (T5SO)(ring sulfoxide) were detected in serum and urine from rats and patients following chronic thioridazine administration. The isolation and identification of each pair of...
5.
6.
Hale Jr P, Poklis A
Toxicol Lett
. 1984 Apr;
21(1):1-8.
PMID: 6719481
The potential cardiotoxicity of a racemic mixture of thioridazine-5-sulfoxide, an oxidative metabolite of thioridazine, was studied in the isolated, perfused rat heart. Thioridazine-5-sulfoxide (ring sulfoxide) was prepared by a new...
7.
Hale Jr P, Poklis A
J Anal Toxicol
. 1983 Sep;
7(5):249-51.
PMID: 6645409
An evaluation of a new colorimetric assay (SIGMA-430) for the rapid determination of acetaminophen in serum or plasma was performed. Acetaminophen was reacted with nitrous acid to form a 2-nitro-5-acetamidophenol...