P T Sharpe
Overview
Explore the profile of P T Sharpe including associated specialties, affiliations and a list of published articles.
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Articles
141
Citations
3172
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Recent Articles
1.
James E, Caetano A, Sharpe P
J Dent Res
. 2024 Sep;
103(13):1340-1348.
PMID: 39272216
Observation is at the center of all biological sciences. Advances in imaging technologies are therefore essential to derive novel biological insights to better understand the complex workings of living systems....
2.
Caetano A, Sharpe P
J Dent Res
. 2024 Jan;
103(2):129-137.
PMID: 38166489
The human oral mucosa contains one of the most complex cellular systems that are essential for normal physiology and defense against a wide variety of local pathogens. Evolving techniques and...
3.
Alaohali A, Salzlechner C, Zaugg L, Suzano F, Martinez A, Gentleman E, et al.
J Dent Res
. 2021 Jun;
101(1):46-53.
PMID: 34152872
Small-molecule drugs targeting glycogen synthase kinase 3 (GSK3) as inhibitors of the protein kinase activity are able to stimulate reparative dentine formation. To develop this approach into a viable clinical...
4.
Contessi Negrini N, Angelova Volponi A, Higgins C, Sharpe P, Celiz A
Mater Today Bio
. 2021 Apr;
10:100107.
PMID: 33889838
Tissue engineering (TE) is a multidisciplinary research field aiming at the regeneration, restoration, or replacement of damaged tissues and organs. Classical TE approaches combine scaffolds, cells and soluble factors to...
5.
Zaugg L, Banu A, Walther A, Chandrasekaran D, Babb R, Salzlechner C, et al.
J Dent Res
. 2020 Mar;
99(5):544-551.
PMID: 32156176
The canonical Wnt/β-catenin signaling pathway is crucial for reparative dentinogenesis following tooth damage, and the modulation of this pathway affects the rate and extent of reparative dentine formation in damaged...
6.
Yelick P, Sharpe P
J Dent Res
. 2019 Sep;
98(11):1173-1182.
PMID: 31538866
Over the past 100 y, tremendous progress has been made in the fields of dental tissue engineering and regenerative dental medicine, collectively known as translational dentistry. Translational dentistry has benefited...
7.
Yianni V, Sharpe P
J Dent Res
. 2019 Jul;
98(10):1066-1072.
PMID: 31276626
Cells have been identified in postnatal tissues that, when isolated from multiple mesenchymal compartments, can be stimulated in vitro to give rise to cells that resemble mature mesenchymal phenotypes, such...
8.
Babb R, Chandrasekaran D, Zaugg L, Sharpe P
Methods Mol Biol
. 2019 Mar;
1922:111-119.
PMID: 30838569
Different animal models have been introduced recently to study the process of reparative dentinogenesis in response to injury-induced pulp exposure. Using a mouse model is advantageous over other animal models...
9.
Abid M, Simpson M, Barbosa I, Seppala M, Irving M, Sharpe P, et al.
Orthod Craniofac Res
. 2018 Jun;
PMID: 29927056
Objectives: To identify the genetic basis of severe tooth agenesis in a family of three affected sisters. Patients And Methods: A family of three sisters with severe tooth agenesis was...
10.
Neves V, Sharpe P
J Dent Res
. 2017 Nov;
97(4):416-422.
PMID: 29185832
During the treatment of dental caries that has not penetrated the tooth pulp, maintenance of as much unaffected dentine as possible is a major goal during the physical removal of...