P T Francis
Overview
Explore the profile of P T Francis including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
96
Citations
1666
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Clarke E, Jantrachotechatchawan C, Buhidma Y, Broadstock M, Yu L, Howlett D, et al.
Neurochem Int
. 2019 Jul;
129:104502.
PMID: 31299418
Heterozygous mutations in GBA1, the gene which encodes the lysosomal enzyme glucocerebrosidase (GCase), are a strong genetic risk factor for the development of Lewy body dementia (LBD). Until this point...
2.
Patel T, Brookes K, Turton J, Chaudhury S, Guetta-Baranes T, Guerreiro R, et al.
Neuropathol Appl Neurobiol
. 2017 Nov;
44(5):506-521.
PMID: 29181857
Aim: Late-onset Alzheimer's disease (LOAD) accounts for 95% of all Alzheimer's cases and is genetically complex in nature. Overlapping clinical and neuropathological features between AD, FTD and Parkinson's disease highlight...
3.
Cidis Meltzer C, Francis P
Dialogues Clin Neurosci
. 2011 Oct;
3(3):167-80.
PMID: 22034395
Remarkable and continued growth in the field of brain aging research has been fueled by a confluence of factors. Developments in molecular biology, imaging, and genetics coupled with the imperative...
4.
Kirvell S, Elliott M, Kalaria R, Hortobagyi T, Ballard C, Francis P
Neurology
. 2010 Nov;
75(20):1803-9.
PMID: 21079182
Objectives: Vascular dementia (VaD) accounts for approximately 15%-20% of all dementias, but the relationship of progressive cognitive impairment to neurochemical changes is poorly understood. We have therefore investigated glutamatergic synaptic...
5.
Francis P
Curr Mol Pharmacol
. 2009 Dec;
2(1):77-82.
PMID: 20021448
Behavioural symptoms are a significant problem in Alzheimer's disease (AD). Symptoms including agitation/aggression and psychosis reduce patient quality of life, significantly increase caregiver burden, and often trigger nursing home placement....
6.
Tsang S, Francis P, Esiri M, Wong P, Chen C, Lai M
Psychopharmacology (Berl)
. 2008 Apr;
198(2):251-9.
PMID: 18373228
Rationale: Neuropsychiatric behaviours in Alzheimer's disease (AD) patients have been associated with neocortical alterations of presynaptic cholinergic and muscarinic M2 receptor markers. In contrast, it is unclear whether non-M2 muscarinic...
7.
Bowen D, Procter A, Mann D, Snowden J, Esiri M, Neary D, et al.
Psychopharmacology (Berl)
. 2007 Nov;
196(4):603-10.
PMID: 18026720
Rationale: Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). Objectives: To evaluate in FTD with the...
8.
Holmes C, McCulley M, Nicoll J, Alder J, Chen C, Francis P
Neurosci Lett
. 2007 May;
420(1):58-60.
PMID: 17481814
A common intronic single nucleotide polymorphism (T102C) in the 5-HT2A receptor gene is associated with the development of different neuropsychiatric symptoms, including hallucinations and depressive symptoms in Alzheimer's disease (AD)....
9.
Jacobs E, Williams R, Francis P
Neuroscience
. 2006 Jan;
138(2):511-22.
PMID: 16413130
Besides formation of neurofibrillary tangles and neuron loss, the Alzheimer's disease brain is characterized by neuritic plaques consisting of beta-amyloid peptide deposits and impaired neurotransmission. The proteins Munc18a, Munc18-interacting protein...
10.
Garcia-Alloza M, Gil-Bea F, Diez-Ariza M, Chen C, Francis P, Lasheras B, et al.
Neuropsychologia
. 2005 Feb;
43(3):442-9.
PMID: 15707619
Neuropsychiatric symptoms seen in Alzheimer's disease (AD) are not simply a consequence of neurodegeneration, but probably result from differential neurotransmitter alterations, which some patients are more at risk of than...