P Polc
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Explore the profile of P Polc including associated specialties, affiliations and a list of published articles.
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41
Citations
612
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Recent Articles
1.
Polc P, Schneeberger J, Haefely W
Neurosci Lett
. 2009 Jul;
9(1):33-6.
PMID: 19605190
No abstract available.
2.
Polc P, Jahromi S, Facciponte G, Pelletier M, Zhang L, Carlen P
Epilepsia
. 1996 Oct;
37(10):1007-14.
PMID: 8822701
Purpose: The antiepileptic effects of benzodiazepine-receptor (BZR) agonists have been well documented. Surprisingly, an antiepileptic effect for the BZR antagonist, flumazenil, has also been described, the mechanism of which is...
3.
Polc P, Jahromi S, Facciponte G, Pelletier M, Zhang L, Carlen P
Neuroreport
. 1995 Jul;
6(11):1549-52.
PMID: 7579146
We examined the effects of the benzodiazepine antagonist, flumazenil, on epileptiform discharges evoked in the hippocampal CA1 region in vitro. Application of 100 nM flumazenil did not affect normal synaptic...
4.
Polc P
Med Hypotheses
. 1995 Jun;
44(6):439-46.
PMID: 7476587
Many therapeutic effects of benzodiazepines are mediated by neuronal high-affinity binding sites, i.e. benzodiazepine receptors (BR), located on GABAA receptors. Recently, endogenous BR ligands have partially been identified which, as...
5.
Polc P, Ducic I
Neuropharmacology
. 1991 Jan;
30(1):107-11.
PMID: 1646418
The interaction between the GABAA receptor antagonist bicuculline and the benzodiazepine receptor (BR) antagonist flumazenil was studied in the lumbosacral cord of spinal cats. Bicuculline (0.8 mg/kg i.v.) evoked epileptiform...
6.
Polc P, Ducic I
Brain Res
. 1990 Oct;
531(1-2):286-9.
PMID: 1963101
Switching from a low (0.5 Hz) to a higher (5 Hz) frequency repetitive stimulation of hindlimb muscle nerve afferents reduced GABA-mediated dorsal root potentials and dorsal root reflexes in the...
7.
BURKARD W, Bonetti E, Da Prada M, Martin J, Polc P, SCHAFFNER R, et al.
J Pharmacol Exp Ther
. 1989 Jan;
248(1):391-9.
PMID: 2913284
The novel antidepressant moclobemide is a reversible inhibitor of monoamine oxidase (MAO), preferentially of type A. Moclomide was active in three animal models considered predictive for antidepressant activity: 1) it...
8.
Bonetti E, BURKARD W, Gabl M, Hunkeler W, LOREZ H, Martin J, et al.
Pharmacol Biochem Behav
. 1988 Nov;
31(3):733-49.
PMID: 2855118
The imidazobenzodiazepinone derivative Ro 15-4513 has the activity profile of a partial inverse (low efficacy) agonist at the benzodiazepine receptor (BZR). It reverses central nervous depressant effects of diazepam, and,...
9.
Polc P
Prog Neurobiol
. 1988 Jan;
31(5):349-423.
PMID: 2851856
Electrophysiology of BZR ligands has been reviewed from different points of view. A great effort was made to critically discuss the arguments for and against the temporarily leading hypothesis of...
10.
Polc P
Eur J Pharmacol
. 1987 Nov;
144(1):113-5.
PMID: 2830118
The effects of 3-((+/-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a selective and potent antagonist of N-methyl-D-aspartic acid (NMDA) receptors, were studied on gamma-motoneurone activity in the spinal cord of unanaesthetized spinal cats. CPP...