P L Carlen
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Explore the profile of P L Carlen including associated specialties, affiliations and a list of published articles.
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185
Citations
2353
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Recent Articles
1.
Florez C, Lukankin V, Sugumar S, McGinn R, Zhang Z, Zhang L, et al.
Neurobiol Dis
. 2015 Jun;
82:213-225.
PMID: 26093168
Unlabelled: Seizures are the most common clinical presentation of severe hypoglycemia, usually as a side effect of insulin treatment for juvenile onset type 1 diabetes mellitus and advanced type 2...
2.
Florez C, McGinn R, Lukankin V, Marwa I, Sugumar S, Dian J, et al.
Cereb Cortex
. 2013 Sep;
25(3):578-97.
PMID: 24046077
Electrophysiological oscillations are thought to create temporal windows of communication between brain regions. We show here that human cortical slices maintained in vitro can generate oscillations similar to those observed...
3.
Aziz J, Genov R, Bardakjian B, Derchansky M, Carlen P
IEEE Trans Biomed Circuits Syst
. 2013 Jul;
1(1):56-62.
PMID: 23851521
A 256-channel integrated interface for simultaneous recording of distributed neural activity from acute brain slices is presented. An array of 16 times 16 Au recording electrodes are fabricated directly on...
4.
Zhang Z, Valiante T, Carlen P
Epilepsy Res
. 2011 Nov;
97(3):290-9.
PMID: 22075227
One of the most terrifying aspects of epilepsy is the sudden and apparently unpredictable transition of the brain into the pathological state of an epileptic seizure. The pathophysiology of the...
5.
Cotic M, Chiu A, Jahromi S, Carlen P, Bardakjian B
J Neural Eng
. 2011 Jun;
8(4):046024.
PMID: 21712570
To study cell-field dynamics, physiologists simultaneously record local field potentials and the activity of individual cells from animals performing cognitive tasks, during various brain states or under pathological conditions. However,...
6.
Shahar E, Derchansky M, Carlen P
Clin Neurophysiol
. 2009 Mar;
120(4):673-8.
PMID: 19299198
Objectives: To study the role of altered tissue osmolality on the characteristics and propagation dynamics of seizure activity and on interictal activity, in a low-Mg(+2) artificial cerebrospinal fluid (ACSF) model...
7.
Tonkikh A, Carlen P
Neuroscience
. 2009 Feb;
159(4):1300-8.
PMID: 19215725
Impaired regulation of presynaptic intracellular calcium is thought to adversely affect synaptic plasticity and cognition in the aged brain. We studied presynaptic cytosolic and mitochondrial calcium (Ca) dynamics using axonally...
8.
Shin D, Carlen P
J Neurophysiol
. 2008 Feb;
99(5):2203-19.
PMID: 18305090
High-frequency stimulation (HFS) is used to treat a variety of neurological diseases, yet its underlying therapeutic action is not fully elucidated. Previously, we reported that HFS-induced elevation in [K(+)](e) or...
9.
Derchansky M, Jahromi S, Mamani M, Shin D, Sik A, Carlen P
J Physiol
. 2007 Nov;
586(2):477-94.
PMID: 17991696
The neural dynamics and mechanisms responsible for the transition from the interictal to the ictal state (seizures) are unresolved questions in epilepsy. It has been suggested that a shift from...
10.
Shin D, Samoilova M, Cotic M, Zhang L, Brotchie J, Carlen P
Neuroscience
. 2007 Sep;
149(1):68-86.
PMID: 17826920
High frequency stimulation (HFS) is applied to many brain regions to treat a variety of neurological disorders/diseases, yet the mechanism(s) underlying its effects remains unclear. While some studies showed that...