P Pedarzani
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Explore the profile of P Pedarzani including associated specialties, affiliations and a list of published articles.
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15
Citations
928
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Recent Articles
1.
Pedarzani P, Stocker M
Cell Mol Life Sci
. 2008 Jul;
65(20):3196-217.
PMID: 18597044
Small conductance calcium-activated potassium (SK or K(Ca)2) channels link intracellular calcium transients to membrane potential changes. SK channel subtypes present different pharmacology and distribution in the nervous system. The selective...
2.
Kulik A, Brockhaus J, Pedarzani P, Ballanyi K
Neuroscience
. 2002 Mar;
110(3):541-54.
PMID: 11906792
The contribution of subclasses of K(+) channels to the response of mammalian neurons to anoxia is not yet clear. We investigated the role of ATP-sensitive (K(ATP)) and Ca(2+)-activated K(+) currents...
3.
Savic N, Pedarzani P, Sciancalepore M
J Neurophysiol
. 2001 May;
85(5):1986-97.
PMID: 11353015
Stratum (st.) radiatum interneurons represent a heterogeneous class of hippocampal cells with as yet poorly characterized physiological properties. Intracellular staining with biocytin, in situ hybridization, and patch-clamp recording have been...
4.
Pedarzani P, Mosbacher J, Rivard A, Cingolani L, Oliver D, Stocker M, et al.
J Biol Chem
. 2001 Jan;
276(13):9762-9.
PMID: 11134030
In most central neurons, action potentials are followed by an afterhyperpolarization (AHP) that controls firing pattern and excitability. The medium and slow components of the AHP have been ascribed to...
5.
Pedarzani P, Kulik A, Muller M, Ballanyi K, Stocker M
J Physiol
. 2000 Sep;
527 Pt 2:283-90.
PMID: 10970429
Using in situ hybridisation histochemistry in combination with patch-clamp recordings and specific pharmacological tools, the molecular nature of the channels underlying Ca2+-dependent K+ currents was determined in dorsal vagal neurones...
6.
Stocker M, Pedarzani P
Mol Cell Neurosci
. 2000 Jun;
15(5):476-93.
PMID: 10833304
Ca(2+)-activated, voltage-independent K(+) channels are present in most neurons and mediate the afterhyperpolarizations (AHPs) following action potentials. They present distinct physiological and pharmacological properties and play an important role in...
7.
Krause M, Pedarzani P
Neuropharmacology
. 2000 Apr;
39(7):1274-83.
PMID: 10760369
The slow calcium-activated potassium current sI(AHP) underlies spike-frequency adaptation and has a substantial impact on the excitability of hippocampal CA1 pyramidal neurons. Among other neuromodulatory substances, sI(AHP) is modulated by...
8.
Stocker M, Krause M, Pedarzani P
Proc Natl Acad Sci U S A
. 1999 Apr;
96(8):4662-7.
PMID: 10200319
In hippocampal and other cortical neurons, action potentials are followed by afterhyperpolarizations (AHPs) generated by the activation of small-conductance Ca2+-activated K+ channels (SK channels). By shaping the neuronal firing pattern,...
9.
Pedarzani P, Krause M, Haug T, Storm J, Stuhmer W
J Neurophysiol
. 1998 Jun;
79(6):3252-6.
PMID: 9636123
The slow Ca2+-activated K+ current, sIAHP, underlying spike frequency adaptation, was recorded with the whole cell patch-clamp technique in CA1 pyramidal neurons in rat hippocampal slices. Inhibitors of serine/threonine protein...
10.
Pedarzani P, Storm J
Eur J Neurosci
. 1996 Oct;
8(10):2098-110.
PMID: 8921301
Noradrenaline inhibits the Ca(2+)-activated K+ current IAHP, which underlies the slow afterhyperpolarization and spike frequency adaptation in hippocampal and neocortical neurons. The resulting increase in excitability probably contributes to the...