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P Pauwels

Explore the profile of P Pauwels including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 73
Citations 980
Followers 0
Related Specialties
Oncology
Pathology
General Medicine
Top 10 Co-Authors
P Dal Cin
H Van Den Berghe
R Sciot
M Peeters
L T Vlasveld
C Rolfo
P Moerman
F Lardon
V Deschoolmeester
P A van Dam
Published In
Histopathology
Genes Chromosomes Cancer
Cancer Genet Cytogenet
Lung Cancer
Br J Cancer
Affiliations
Soon will be listed here.
Recent Articles
1.
Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europe
Hofman P, Calabrese F, Kern I, Adam J, Alarcao A, Alborelli I, et al.
ESMO Open . 2023 Sep; 8(5):101628. PMID: 37713929
Background: Testing for epidermal growth factor receptor (EGFR) mutations is an essential recommendation in guidelines for metastatic non-squamous non-small-cell lung cancer, and is considered mandatory in European countries. However, in...
2.
PRECISION: the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment
Thouvenin J, van Marcke C, Decoster L, Raicevic G, Punie K, Vandenbulcke M, et al.
ESMO Open . 2022 Aug; 7(4):100524. PMID: 35970014
PRECISION is an initiative from the Belgian Society of Medical Oncology (BSMO) in collaboration with several stakeholders, encompassing four programs that aim to boost genomic and clinical knowledge with the...
3.
Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future
Hofman P, Ilie M, Chamorey E, Brest P, Schiappa R, Nakache V, et al.
ESMO Open . 2021 Jan; 6(1):100024. PMID: 33399086
Background: This study evaluated the consequences in Europe of the COVID-19 outbreak on pathology laboratories orientated toward the diagnosis of thoracic diseases. Materials And Methods: A survey was sent to...
4.
ALK immunohistochemistry positive, FISH negative NSCLC is infrequent, but associated with impaired survival following treatment with crizotinib
Thunnissen E, Lissenberg-Witte B, van den Heuvel M, Monkhorst K, Skov B, Sorensen J, et al.
Lung Cancer . 2019 Oct; 138:13-18. PMID: 31630043
Objective: Metastasized non-small cell lung cancer (NSCLC) with an anaplastic lymphoma kinase (ALK) rearrangement is usually sensitive to a range of ALK-tyrosine kinase inhibitors. ALK-positive NSCLC have been identified in...
5.
Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms
Vandamme T, Beyens M, Boons G, Schepers A, Kamp K, Biermann K, et al.
Endocr Relat Cancer . 2018 Jul; 26(1):1-12. PMID: 30021865
Mutations in DAXX/ATRX, MEN1 and genes involved in the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway have been implicated in pancreatic neuroendocrine neoplasms (pNENs). However, mainly mutations present in the majority...
6.
Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo
Lambrecht C, Libbrecht L, Sagaert X, Pauwels P, Hoorne Y, Crowther J, et al.
Oncogene . 2017 Oct; 37(4):544-552. PMID: 28967903
Protein Phosphatase 2A (PP2A) enzymes counteract diverse kinase-driven oncogenic pathways and their function is frequently impaired in cancer. PP2A inhibition is indispensable for full transformation of human cells, but whether...
7.
Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer
Valentino A, Reclusa P, Sirera R, Giallombardo M, Camps C, Pauwels P, et al.
Clin Transl Oncol . 2017 Jan; 19(6):651-657. PMID: 28054319
Prostate cancer is the second most diagnosed cancer in males in the world. Plasma quantification of prostate-specific antigen substantially improved the early detection of prostate cancer, but still lacks the...
8.
Effectiveness of crizotinib in a patient with ALK IHC-positive/FISH-negative metastatic lung adenocarcinoma
Rosoux A, Pauwels P, Duplaquet F, DHaene N, Weynand B, Delos M, et al.
Lung Cancer . 2016 Jul; 98:118-121. PMID: 27393517
We report a case of crizotinib effectiveness in a heavily pretreated patient with a metastatic NSCLC initially considered IHC-positive and FISH-negative for ALK rearrangement. After repeated analyses of tumor samples,...
9.
Preclinical and clinical studies on afatinib in monotherapy and in combination regimens: Potential impact in colorectal cancer
De Pauw I, Wouters A, Van den Bossche J, Peeters M, Pauwels P, Deschoolmeester V, et al.
Pharmacol Ther . 2016 Jul; 166:71-83. PMID: 27373506
Targeting the epidermal growth factor receptor (EGFR) with monoclonal antibodies (mAbs) or tyrosine kinase inhibitors (TKI) has been an interesting therapeutic strategy because aberrant activation of this receptor plays an...
10.
Circulating cell-free nucleic acids and platelets as a liquid biopsy in the provision of personalized therapy for lung cancer patients
Sorber L, Zwaenepoel K, Deschoolmeester V, Van Schil P, Van Meerbeeck J, Lardon F, et al.
Lung Cancer . 2016 May; 107:100-107. PMID: 27180141
Lung cancer is the predominant cause of cancer-related mortality in the world. The majority of patients present with locally advanced or metastatic non-small-cell lung cancer (NSCLC). Treatment for NSCLC is...