P P Ruvolo
Overview
Explore the profile of P P Ruvolo including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
628
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Recent Articles
1.
Lesyk G, Fong T, Ruvolo P, Jurasz P
J Thromb Haemost
. 2015 May;
13(8):1514-20.
PMID: 25990653
Background: Enzastaurin is a protein kinase C (PKC)β inhibitor with antiproliferative and proapoptotic effects that was in clinical development for the treatment of a variety of cancers. However, the primary...
2.
Ruvolo P, Qui Y, Coombes K, Zhang N, Ruvolo V, Borthakur G, et al.
Leukemia
. 2011 Jun;
25(11):1711-7.
PMID: 21660042
The regulation of protein kinase B (AKT) is a dynamic process that depends on the balance between phosphorylation by upstream kinases for activation and inactivation by dephosphorylation by protein phosphatases....
3.
Kong G, Wang D, Wang H, Wu J, Bielawski J, Konopleva M, et al.
Leukemia
. 2007 Nov;
22(6):1258-62.
PMID: 18033322
No abstract available.
4.
Kurinna S, Konopleva M, Palla S, Chen W, Kornblau S, Contractor R, et al.
Leukemia
. 2006 Apr;
20(7):1316-9.
PMID: 16642043
No abstract available.
5.
Konopleva M, Contractor R, Kurinna S, Chen W, Andreeff M, Ruvolo P
Leukemia
. 2005 Jun;
19(8):1350-4.
PMID: 15931262
Development of novel therapeutic strategies is a continuing challenge for the treatment of acute myeloid leukemia (AML). The novel triterpenoid, C-28 methyl ester of 2-cyano-3,12-dioxoolen-1,9-dien-28-oic acid (CDDO-Me), induces apoptosis in...
6.
Jiffar T, Kurinna S, Suck G, Carlson-Bremer D, Ricciardi M, Konopleva M, et al.
Leukemia
. 2004 Jan;
18(3):505-12.
PMID: 14737078
Overexpression of protein kinase C alpha (PKC alpha) promotes Bcl2 phosphorylation and chemoresistance in human acute leukemia cells. The contribution of non-Bcl2 mechanisms in this process is currently unknown. In...
7.
Johnson C, Jiffar T, Fischer U, Ruvolo P, Jarvis W
Leukemia
. 2003 Sep;
17(11):2140-8.
PMID: 12970763
The present studies examined performance of SAPK cascades and apoptotic commitment following ribosomal trauma in REH lymphoid leukemia cells. Ribostatic insults included disruption of ribosomal activity by mechanistically dissimilar agents...
8.
Ruvolo P
Leukemia
. 2001 Aug;
15(8):1153-60.
PMID: 11480555
The sphingolipid ceramide is an important second signal molecule that regulates diverse signaling pathways involving apoptosis, cell senescence, the cell cycle, and differentiation. For the most part, ceramide's effects are...
9.
Ruvolo P, Deng X, May W
Leukemia
. 2001 May;
15(4):515-22.
PMID: 11368354
Members of the Bcl2 family of proteins are important regulators of programmed cell death pathways with individual members that can suppress (eg Bcl2, Bcl-XL) or promote (eg Bax, Bad) apoptosis....
10.
Deng X, Kornblau S, Ruvolo P, May Jr W
J Natl Cancer Inst Monogr
. 2001 Feb;
(28):30-7.
PMID: 11158204
Although considered tightly linked, the linkage effectors for proliferation and antiapoptotic signaling pathways are not clear. Phosphorylation of Bcl2 at serine 70 is required for suppression of apoptosis in interleukin...