P P Mueller
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Explore the profile of P P Mueller including associated specialties, affiliations and a list of published articles.
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11
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Recent Articles
1.
Geserick C, Bonarius H, Kongerslev L, Hauser H, Mueller P
Biotechnol Bioeng
. 2000 Jun;
69(3):266-74.
PMID: 10861406
A perfused cell-culture process was developed to investigate the stability of IRF-1-mediated proliferation control in BHK cells and to evaluate the efficacy of a novel promoter in these cells. The...
2.
Mueller P, Schlenke P, Nimtz M, Conradt H, Hauser H
Biotechnol Bioeng
. 1999 Oct;
65(5):529-36.
PMID: 10516578
We analyzed product quality to determine the applicability of proliferation-controlled mammalian cells for recombinant pharmaceutical protein production. Baby hamster kidney (BHK)-21 cells were engineered to express a dicistronic, stabilized, self-selecting...
3.
Fussenegger M, Bailey J, Hauser H, Mueller P
Trends Biotechnol
. 1999 Mar;
17(1):35-42.
PMID: 10098276
Genetically modified mammalian cells are the preferred system for the production of recombinant therapeutic glycoproteins. Other applications include engineering of cell lines for drug screening and cell-based therapies, and the...
4.
Mueller P, Grueter P, Hinnebusch A, Trachsel H
J Biol Chem
. 1998 Nov;
273(49):32870-7.
PMID: 9830035
In amino acid-starved yeast cells, inhibition of the guanine nucleotide exchange factor eIF2B by phosphorylated translation initiation factor 2 results in increased translation of GCN4 mRNA. We isolated a suppressor...
5.
Lanker S, Bushman J, Hinnebusch A, Trachsel H, Mueller P
Cell
. 1992 Aug;
70(4):647-57.
PMID: 1505029
We cloned the GCD5 gene of S. cerevisiae and found it to be identical to KRS1, which encodes lysyl-tRNA synthetase (LysRS). The mutation gcd5-1 changes a conserved residue in the...
6.
Mueller P, Jackson B, Miller P, Hinnebusch A
Mol Cell Biol
. 1988 Dec;
8(12):5439-47.
PMID: 3072481
The third and fourth AUG codons in GCN4 mRNA efficiently repress translation of the GCN4-coding sequences under normal growth conditions. The first AUG codon is approximately 30-fold less inhibitory and...
7.
Hinnebusch A, Jackson B, Mueller P
Proc Natl Acad Sci U S A
. 1988 Oct;
85(19):7279-83.
PMID: 3050993
Translational control of the GCN4 gene of Saccharomyces cerevisiae is mediated by four upstream open reading frames (URFs) present in the leader of GCN4 mRNA. URFs 3 and 4 efficiently...
8.
Williams N, Mueller P, Hinnebusch A
Mol Cell Biol
. 1988 Sep;
8(9):3827-36.
PMID: 3065626
Translational control of GCN4 expression in the yeast Saccharomyces cerevisiae is mediated by multiple AUG codons present in the leader of GCN4 mRNA, each of which initiates a short open...
9.
Mueller P, Harashima S, Hinnebusch A
Proc Natl Acad Sci U S A
. 1987 May;
84(9):2863-7.
PMID: 3554249
GCN4 encodes a transcriptional activator in Saccharomyces cerevisiae that is regulated at the translational level. We show that an approximately 240-nucleotide segment from the GCN4 mRNA leader containing four AUG...
10.
Mueller P, Hinnebusch A
Cell
. 1986 Apr;
45(2):201-7.
PMID: 3516411
GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in yeast that is regulated at the translational level. The 5' leader of GCN4 mRNA contains four small open-reading-frames. By...