P N E De Graan
Overview
Explore the profile of P N E De Graan including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
496
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Recent Articles
1.
Nelson T, Olde Engberink A, Hernandez R, Puro A, Huitron-Resendiz S, Hao C, et al.
Brain Behav Immun
. 2012 May;
26(6):959-71.
PMID: 22609298
Elevated levels of the inflammatory cytokine interleukin-6 (IL-6) occur in a number of CNS disorders. However, little is known about how this condition affects CNS neuronal function. Transgenic mice that...
2.
Kuijpers M, van Gassen K, De Graan P, Gruol D
J Neuroimmunol
. 2010 Aug;
229(1-2):73-80.
PMID: 20678811
We examined the effect of chronic CCL3 treatment on the properties of cultured rat hippocampal neurons to gain an understanding of the neuronal effects of CCL3 during neuroinflammatory disorders. Western...
3.
Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures
van Gassen K, van der Hel W, Hakvoort T, Lamers W, De Graan P
Genes Brain Behav
. 2009 Jan;
8(3):290-5.
PMID: 19170755
Glutamine synthetase (GS) is a pivotal glial enzyme in the glutamate-glutamine cycle. GS is important in maintaining low extracellular glutamate concentrations and is downregulated in the hippocampus of temporal lobe...
4.
Hessel E, van Gassen K, Wolterink-Donselaar I, Stienen P, Fernandes C, Brakkee J, et al.
Genes Brain Behav
. 2008 Dec;
8(2):248-55.
PMID: 19077119
Febrile seizures (FS) are the most common seizure type in children and recurrent FS are a risk factor for developing temporal lobe epilepsy. Although the mechanisms underlying FS are largely...
5.
Kas M, de Mooij-van Malsen J, De Krom M, van Gassen K, van Lith H, Olivier B, et al.
Genes Brain Behav
. 2008 Aug;
8(1):13-22.
PMID: 18721260
The generation of motor activity levels is under tight neural control to execute essential behaviors, such as movement toward food or for social interaction. To identify novel neurobiological mechanisms underlying...
6.
van Gassen K, Hessel E, Ramakers G, Notenboom R, Wolterink-Donselaar I, Brakkee J, et al.
Genes Brain Behav
. 2008 Mar;
7(5):578-86.
PMID: 18363854
Febrile seizures (FS) are the most prevalent seizures in children. Although FS are largely benign, complex FS increase the risk to develop temporal lobe epilepsy (TLE). Studies in rat models...
7.
Noorlander C, Visser G, Ramakers G, Nikkels P, De Graan P
Dev Neurobiol
. 2007 Nov;
68(2):237-46.
PMID: 18000831
Synthetic corticosteroids, such as dexamethasone, are frequently administered to pregnant women at risk for preterm delivery. Endogenous corticosteroids are essential for normal development, but exposure to therapeutic doses at critical...
8.
Noorlander C, De Graan P, Middeldorp J, van Beers J, Visser G
J Comp Neurol
. 2006 Oct;
499(6):924-32.
PMID: 17072842
Women at risk for preterm delivery are treated with synthetic glucocorticoids (GCs) to enhance fetal lung maturation. GCs can bind to two intracellular receptors, the glucocorticoid receptor (GR) and the...
9.
Bos I, Hoogland G, Meine Jansen C, van Willigen G, Spierenburg H, van den Berg L, et al.
Neurochem Int
. 2006 Jan;
48(4):306-11.
PMID: 16426705
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and glutamate excitotoxicity has been implicated in its pathogenesis. Platelets contain a glutamate uptake system and express components of the glutamate-glutamine cycle,...
10.
Hoogland G, Bos I, Kupper F, van Willigen G, Spierenburg H, van Nieuwenhuizen O, et al.
Neurochem Int
. 2005 Sep;
47(7):499-506.
PMID: 16137792
Glutamate toxicity has been implicated in the pathogenesis of various neurological diseases. Glial glutamate transporters play a key role in the regulation of extracellular glutamate levels in the brain by...