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P Meera Khan

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Articles 137
Citations 1505
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Recent Articles
1.
Fodde R, Smits R, Hofland N, Kielman M, Meera Khan P
Cytogenet Cell Genet . 1999 Nov; 86(2):105-11. PMID: 10545699
Colorectal cancer still represents one of the most common causes of morbidity and mortality among Western populations. The adenomatous polyposis coli (APC) gene, originally identified as the gene responsible for...
2.
van der Houven van Oordt C, Smits R, Schouten T, Houwing-Duistermaat J, Williamson S, Luz A, et al.
Genes Chromosomes Cancer . 1999 Aug; 24(3):191-8. PMID: 10451698
The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids...
3.
Vasen H, van Ballegooijen M, Buskens E, Kleibeuker J, Taal B, Griffioen G, et al.
Cancer . 1998 May; 82(9):1632-7. PMID: 9576281
Background: It has been estimated that the prevalence of carriers of a mutated mismatch repair (MMR) gene among the general population in Western countries is between 5 and 50 per...
4.
van der Luijt R, Meera Khan P, Vasen H, Breukel C, Tops C, Scott R, et al.
Hum Genet . 1996 Dec; 98(6):727-34. PMID: 8931709
Familial adenomatous polyposis (FAP) is an inherited predisposition to colorectal cancer characterized by the development of numerous adenomatous polyps predominantly in the colorectal region. Germline mutations in the adenomatous polyposis...
5.
Bala S, Kraus C, Wijnen J, Meera Khan P, Ballhausen W
Hum Genet . 1996 Nov; 98(5):528-33. PMID: 8882870
Reverse transcription-polymerase chain reaction (RT-PCR)-based analyses of the adenomatous polyposis coli (APC) gene encompassing exons 1-15 revealed a complex pattern of products that were due to alternative splicing of exons...
6.
Vasen H, van der Luijt R, Slors J, Buskens E, de Ruiter P, Baeten C, et al.
Lancet . 1996 Aug; 348(9025):433-5. PMID: 8709782
Background: In familial adenomatous polyposis the only curative treatment is colectomy, and the choice of operation lies between restorative proctocolectomy (RPC) and colectomy with ileorectal anastomosis (IRA). The RPC procedure...
7.
Vasen H, Sanders E, Taal B, Nagengast F, Griffioen G, Menko F, et al.
Int J Cancer . 1996 Feb; 65(4):422-5. PMID: 8621220
Hereditary non-polyposis colorectal cancer (HNPCC) is known to be associated with several extracolonic cancers, e.g., cancers of the endometrium, stomach, urinary tract, small bowel and ovary. An association between HNPCC...
8.
van der Luijt R, Vasen H, Tops C, Breukel C, Fodde R, Meera Khan P
Hum Genet . 1995 Dec; 96(6):705-10. PMID: 8522331
Germ-line mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP). Genotype-phenotype correlation studies in patients with FAP have demonstrated associations of certain variants of...
9.
Vasen H, Taal B, Nagengast F, Griffioen G, Menko F, Kleibeuker J, et al.
Eur J Cancer . 1995 Jul; 31A(7-8):1145-8. PMID: 7577010
A surveillance programme comprising either colonoscopy of sigmoidoscopy plus barium enema every 2-3 years was instituted in 50 hereditary nonpolyposis colorectal cancer (HNPCC) families. The families included 238 patients with...
10.
Cornelis R, Vasen H, Meijers-Heijboer H, Ford D, van Vliet M, van Tilborg A, et al.
Hum Genet . 1995 May; 95(5):539-44. PMID: 7759075
We searched for criteria that could indicate breast cancer families with a high prior probability of being caused by the breast/ovarian cancer susceptibility locus BRCA1 on chromosome 17. To this...