P M Hooymans
Overview
Explore the profile of P M Hooymans including associated specialties, affiliations and a list of published articles.
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Articles
48
Citations
290
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0
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Recent Articles
1.
Broekman M, Coenen M, Wanten G, van Marrewijk C, Klungel O, Verbeek A, et al.
Aliment Pharmacol Ther
. 2017 Sep;
46(10):953-963.
PMID: 28914446
Background: Leucopenia is a common side effect in patients treated with thiopurines. Variants in the thiopurine S-methyltransferase (TPMT) gene are the best-known risk factor, but only explain up to 25%...
2.
Wong D, Hooymans P
Aliment Pharmacol Ther
. 2017 Feb;
45(6):858-859.
PMID: 28211625
No abstract available.
3.
van Moorsel S, Bevers N, Meurs M, van Rossum L, Hooymans P, Wong D
Ther Drug Monit
. 2017 Jan;
39(1):1-4.
PMID: 28081040
We describe the case of a pediatric patient on azathioprine therapy with previously undiagnosed homozygote thiopurine S-methyltransferase (TPMT) deficiency, resulting in myelotoxic thiopurine metabolite levels. The patient was successfully treated...
4.
Broekman M, Wong D, Wanten G, Roelofs H, van Marrewijk C, Klungel O, et al.
Pharmacogenomics J
. 2017 Jan;
18(1):160-166.
PMID: 28045129
The conversion of azathioprine (AZA) to mercaptopurine (MP) is mediated by glutathione transferase Mu1 (GSTM1), alpha1 (GSTA1) and alpha2 (GSTA2). We designed a case-control study with data from the TOPIC...
5.
Wong D, Coenen M, Derijks L, Vermeulen S, van Marrewijk C, Klungel O, et al.
Aliment Pharmacol Ther
. 2016 Dec;
45(3):391-402.
PMID: 27943397
Background: Hepatotoxicity, gastrointestinal complaints and general malaise are common limiting adverse reactions of azathioprine and mercaptopurine in IBD patients, often related to high steady-state 6-methylmercaptopurine ribonucleotide (6-MMPR) metabolite concentrations. Aim:...
6.
Lohman J, Hooymans P, Verhey M, Koten M, Merkus F
Pharm Res
. 2013 Nov;
1(4):187-8.
PMID: 24277291
No abstract available.
7.
Lohman J, Merkus F, Costongs G, Hegtermans E, Hooymans P
Pharm Res
. 2013 Nov;
1(1):49.
PMID: 24277187
No abstract available.
8.
Wong D, Pierik M, Seinen M, van Bodegraven A, Gilissen L, Bus P, et al.
J Crohns Colitis
. 2013 Aug;
8(2):120-8.
PMID: 23932783
Background And Aims: A drug interaction between infliximab and azathioprine has previously been reported in Crohn's disease patients: the concentration of the main active thiopurine metabolites, the 6-thioguanine nucleotides (6-TGN),...
9.
Mares W, Wong D, Gilissen L, Masclee A, Hooymans P, Engels L
J Crohns Colitis
. 2010 Dec;
3(2):128-30.
PMID: 21172256
The immunosuppressive thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP), have proven efficacy in steroid-dependant or refractory inflammatory bowel disease (IBD). In case of TPMT deficiency serious myelosuppression may occur. 6-thioguanine (6-TG),...
10.
de Graaf P, De Boer N, Wong D, Karner S, Jharap B, Hooymans P, et al.
Br J Pharmacol
. 2010 Jul;
160(5):1083-91.
PMID: 20590602
Background And Purpose: 5-aminosalicylate (5-ASA) raises levels of 6-thioguanine nucleotides (6-TGN), the active metabolites of thiopurines such as azathioprine (AZA). Changes in levels of each individual TGN - 6-thioguanosine mono-,...