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» Authors » P L van Lent

P L van Lent

Explore the profile of P L van Lent including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 57
Citations 1084
Followers 0
Related Specialties
Rheumatology
Allergy & Immunology
Pharmacology
Top 10 Co-Authors
W B van den Berg
L B van de Putte
L van den Bersselaar
F A van De Loo
A E Holthuysen
N van Rooijen
L A Joosten
A B Blom
A E van den Hoek
L A Van Den Bersselaar
Published In
Arthritis Rheum
Agents Actions
J Rheumatol
Am J Pathol
Osteoarthritis Cartilage
Affiliations
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Recent Articles
1.
WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis
van den Bosch M, Blom A, Kram V, Maeda A, Sikka S, Gabet Y, et al.
Osteoarthritis Cartilage . 2017 Jul; 25(11):1900-1911. PMID: 28735021
Objective: Increased Wisp1 expression was previously reported in experimental and human osteoarthritis (OA). Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here,...
2.
High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis
de Munter W, van den Bosch M, Sloetjes A, Croce K, Vogl T, Roth J, et al.
Osteoarthritis Cartilage . 2015 Dec; 24(5):844-55. PMID: 26687826
Objective: A relation between osteoarthritis (OA) and increased cholesterol levels is apparent. In the present study we investigate OA pathology in apolipoprotein E (ApoE)(-)(/-) mice with and without a cholesterol-rich...
3.
Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis
Mahler E, Zweers M, van Lent P, Blom A, van den Hoogen F, van den Berg W, et al.
Scand J Rheumatol . 2014 Sep; 44(1):56-60. PMID: 25179566
Objectives: To explore the association between S100A8/A9 serum levels with clinical and structural characteristics of patients with established knee, hip, or hand osteoarthritis (OA). Method: A cross-sectional exploratory study was...
4.
Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis
Hofkens W, Storm G, van den Berg W, van Lent P
Int J Pharm . 2011 Mar; 416(2):486-92. PMID: 21382458
Unlabelled: Encapsulation of glucocorticoids into long-circulating liposomes provides targeting of these drugs to the inflamed synovium in experimental arthritis and thereby strongly improves their therapeutic index. The goal of this...
5.
Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2
van Tits L, Stienstra R, van Lent P, Netea M, Joosten L, Stalenhoef A
Atherosclerosis . 2010 Dec; 214(2):345-9. PMID: 21167486
Objective: Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different...
6.
FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection
Ioan-Facsinay A, de Kimpe S, Hellwig S, van Lent P, Hofhuis F, Van Ojik H, et al.
Immunity . 2002 Mar; 16(3):391-402. PMID: 11911824
The high-affinity receptor for IgG, FcgammaRI, shares its capacity to bind IgG2a immune complexes (IgG2a-IC) with the low-affinity receptor FcgammaRIII and complement factors, hampering the definition of its biological role....
7.
Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis
van Lent P, Nabbe K, Blom A, Holthuysen A, Sloetjes A, van de Putte L, et al.
Am J Pathol . 2001 Dec; 159(6):2309-20. PMID: 11733380
IgG-containing immune complexes, which are found in most RA joints, communicate with hematopoietic cells using three classes of Fc receptors(Fc gamma RI, -II, -III). In a previous study we found...
8.
Uptake of apoptotic leukocytes by synovial lining macrophages inhibits immune complex-mediated arthritis
van Lent P, Licht R, Dijkman H, Holthuysen A, Berden J, van den Berg W
J Leukoc Biol . 2001 Nov; 70(5):708-14. PMID: 11698489
Previously we have shown that synovial lining macrophages (SLMs) determine the onset of experimental immune complex-mediated arthritis (ICA). During joint inflammation, many leukocytes undergo apoptosis, and removal of leukocytes by...
9.
Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation
Bakker A, van De Loo F, van Beuningen H, Sime P, van Lent P, van der Kraan P, et al.
Osteoarthritis Cartilage . 2001 Mar; 9(2):128-36. PMID: 11237660
Objective: To investigate the impact of a prolonged and constant active TGF-beta expression by the synovial lining cells on cartilage and ligamentous joint structures in vivo. Design: An adenoviral vector...
10.
Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)
Blom A, van Lent P, van Vuuren H, Holthuysen A, Jacobs C, van de Putte L, et al.
Arthritis Res . 2000 Nov; 2(6):489-503. PMID: 11056679
STATEMENT OF FINDINGS: We investigated the role of Fc gamma receptors (Fc gamma Rs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice caused...