P J Godowski
Overview
Explore the profile of P J Godowski including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
4018
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Recent Articles
1.
Gewirtz A, Navas T, Lyons S, Godowski P, Madara J
J Immunol
. 2001 Aug;
167(4):1882-5.
PMID: 11489966
Flagellin, the structural component of bacterial flagella, is secreted by pathogenic and commensal bacteria. Flagellin activates proinflammatory gene expression in intestinal epithelia. However, only flagellin that contacts basolateral epithelial surfaces...
2.
Werts C, Tapping R, Mathison J, Chuang T, Kravchenko V, Saint Girons I, et al.
Nat Immunol
. 2001 Mar;
2(4):346-52.
PMID: 11276206
Leptospira interrogans are zoonotic pathogens that have been linked to a recent increased incidence of morbidity and mortality in highly populated tropical urban centers. They are unique among invasive spirochetes...
3.
Arbibe L, Mira J, Teusch N, Kline L, Guha M, Mackman N, et al.
Nat Immunol
. 2001 Mar;
1(6):533-40.
PMID: 11101877
Mammalian Toll-like receptors (TLRs) are expressed on innate immune cells and respond to the membrane components of Gram-positive or Gram-negative bacteria. When activated, they convey signals to transcription factors that...
4.
Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa M, Engele M, Sieling P, et al.
Science
. 2001 Feb;
291(5508):1544-7.
PMID: 11222859
The mammalian innate immune system retains from Drosophila a family of homologous Toll-like receptors (TLRs) that mediate responses to microbial ligands. Here, we show that TLR2 activation leads to killing...
5.
Hertz C, Kiertscher S, Godowski P, Bouis D, Norgard M, Roth M, et al.
J Immunol
. 2001 Feb;
166(4):2444-50.
PMID: 11160304
The ability of dendritic cells (DC) to initiate immune responses in naive T cells is dependent upon a maturation process that allows the cells to develop their potent Ag-presenting capacity....
6.
Tapping R, Akashi S, Miyake K, Godowski P, Tobias P
J Immunol
. 2000 Nov;
165(10):5780-7.
PMID: 11067937
Two members of the mammalian Toll-like receptor (TLR) family, TLR2 and TLR4, have been implicated as receptors mediating cellular activation in response to bacterial LPS. Through the use of mAbs...
7.
Thoma-Uszynski S, Kiertscher S, Ochoa M, Bouis D, Norgard M, Miyake K, et al.
J Immunol
. 2000 Oct;
165(7):3804-10.
PMID: 11034386
Mammalian Toll-like receptors (TLRs) are required for cell activation by bacterial lipoproteins (bLP) and LPS. Stimulation of monocytes with bLP and LPS results in a TLR-dependent induction of immunomodulatory genes...
8.
Brightbill H, Libraty D, Krutzik S, Yang R, Belisle J, Bleharski J, et al.
Science
. 1999 Jul;
285(5428):732-6.
PMID: 10426995
The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that...
9.
Yang R, Mark M, Gurney A, Godowski P
J Immunol
. 1999 Jul;
163(2):639-43.
PMID: 10395652
Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB. Here, we investigate further the events triggered by TLR2 in response to LPS. We...
10.
Modlin R, Brightbill H, Godowski P
N Engl J Med
. 1999 Jun;
340(23):1834-5.
PMID: 10362831
No abstract available.