P J Conn
Overview
Explore the profile of P J Conn including associated specialties, affiliations and a list of published articles.
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87
Citations
3871
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Recent Articles
1.
Gould R, Dencker D, Grannan M, Bubser M, Zhan X, Wess J, et al.
ACS Chem Neurosci
. 2015 Jul;
6(10):1683-95.
PMID: 26176846
The M1 muscarinic acetylcholine receptor (mAChR) subtype has been implicated in the underlying mechanisms of learning and memory and represents an important potential pharmacotherapeutic target for the cognitive impairments observed...
2.
Ghoshal A, Rook J, Dickerson J, Roop G, Morrison R, Jalan-Sakrikar N, et al.
Neuropsychopharmacology
. 2015 Jun;
41(2):598-610.
PMID: 26108886
Schizophrenia patients exhibit deficits in signaling of the M1 subtype of muscarinic acetylcholine receptor (mAChR) in the prefrontal cortex (PFC) and also display impaired cortical long-term depression (LTD). We report...
3.
DAmore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, et al.
Neuropharmacology
. 2014 May;
85:91-103.
PMID: 24859611
Acute treatment with positive allosteric modulators (PAMs) of mGlu1 and mGlu5 metabotropic glutamate receptors (RO0711401 and VU0360172, respectively) reduces the incidence of spike-and wave discharges in the WAG/Rij rat model...
4.
Gregory K, Herman E, Ramsey A, Hammond A, Byun N, Stauffer S, et al.
J Pharmacol Exp Ther
. 2013 Aug;
347(2):438-57.
PMID: 23965381
Impaired transmission through glutamatergic circuits has been postulated to play a role in the underlying pathophysiology of schizophrenia. Furthermore, inhibition of the N-methyl-d-aspartate (NMDA) subtype of ionotropic glutamate receptors (NMDAR)...
5.
Noetzel M, Gregory K, Vinson P, Manka J, Stauffer S, Lindsley C, et al.
Mol Pharmacol
. 2013 Jan;
83(4):835-47.
PMID: 23348500
Metabotropic glutamate receptor 5 (mGlu5) is a target for the treatment of central nervous system (CNS) disorders, such as schizophrenia and Alzheimer's disease. Furthermore, mGlu5 has been shown to play...
6.
Poslusney M, Sevel C, Utley T, Bridges T, Morrison R, Kett N, et al.
Bioorg Med Chem Lett
. 2012 Oct;
22(22):6923-8.
PMID: 23062550
Utilizing a combination of high-throughput and multi-step synthesis, SAR in a novel series of M(1) acetylcholine receptor antagonists was rapidly established. The efforts led to the discovery the highly potent...
7.
Herman E, Bubser M, Conn P, Jones C
Handb Exp Pharmacol
. 2012 Oct;
(213):297-365.
PMID: 23027420
Metabotropic glutamate receptors (mGluRs) represent exciting targets for the development of novel therapeutic agents for schizophrenia. Recent studies indicate that selective activation of specific mGluR subtypes may provide potential benefits...
8.
DAmore V, Santolini I, van Rijn C, Biagioni F, Molinaro G, Prete A, et al.
Neuropharmacology
. 2012 Jun;
66:330-8.
PMID: 22705340
Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous...
9.
Nicoletti F, Bockaert J, Collingridge G, Conn P, Ferraguti F, Schoepp D, et al.
Neuropharmacology
. 2010 Nov;
60(7-8):1017-41.
PMID: 21036182
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective...
10.
Hackler E, Byun N, Jones C, Williams J, Baheza R, Sengupta S, et al.
Neuroscience
. 2010 Mar;
168(1):209-18.
PMID: 20350588
Previous preclinical and clinical studies have demonstrated the efficacy of group II metabotropic glutamate receptor (mGluR) agonists as potential antipsychotics. Recent studies utilizing mGluR2-, mGluR3-, and double knockout mice support...