P Hadaczek
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Explore the profile of P Hadaczek including associated specialties, affiliations and a list of published articles.
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22
Citations
233
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Recent Articles
1.
Samaranch L, Blits B, San Sebastian W, Hadaczek P, Bringas J, Sudhakar V, et al.
Gene Ther
. 2017 Mar;
24(4):253-261.
PMID: 28300083
The present study was designed to characterize transduction of non-human primate brain and spinal cord with AAV5 viral vector after parenchymal delivery. AAV5-CAG-GFP (1 × 10 vector genomes per milliliter...
2.
Samaranch L, Hadaczek P, Kells A, Bringas J, Stockinger D, San Sebastian W, et al.
Gene Ther
. 2015 Oct;
23(4):393-8.
PMID: 26510688
Adeno-associated virus serotype 2 (AAV2) has previously been reported to be a slowly uncoating virus in peripheral tissues, but persistence of intact vector in primate brain has not been explored....
3.
Salegio E, Kells A, Richardson R, Hadaczek P, Forsayeth J, Bringas J, et al.
Hum Gene Ther
. 2010 Apr;
21(9):1093-103.
PMID: 20408734
Gene replacement therapy for the neurological deficits caused by lysosomal storage disorders, such as in Niemann-Pick disease type A, will require widespread expression of efficacious levels of acid sphingomyelinase (ASM)...
4.
Hadaczek P, Gronwald J, Chosia M, Huebner K, Lubinski J
Pol J Pathol
. 2002 Mar;
52(4):199-203.
PMID: 11915181
The genes specifically involved in endometrial cancers have not yet been discovered. The FHIT gene, a tumour suppressor located at 3p14.2, is altered in many human tumours, including those derived...
5.
Hadaczek P, Debniak T, Kurzawski G, Jakubowska A, Huzarski T, Huebner K, et al.
Pol J Pathol
. 2002 Jan;
52(3):125-32.
PMID: 11769399
The majority of hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations in DNA mismatch repair genes, especially in MLH1 and MSH2. Tumours in such patients also show microsatellite instability...
6.
Jakubowska A, Gorski B, Byrski T, Huzarski T, Gronwald J, Menkiszak J, et al.
Hum Mutat
. 2001 Jul;
18(2):149-56.
PMID: 11462239
BRCA1 mutation detection is expensive and has sensitivity limitations, which might at least partially be overcome by RNA-based sequencing. There are claims that RNA tests are unreliable due to differential...
7.
Jakubowska A, Gorski B, Kurzawski G, Debniak T, Hadaczek P, Cybulski C, et al.
Hum Mutat
. 2001 Jan;
17(1):52-60.
PMID: 11139242
The most sensitive technique for the detection of germline mutations is exon by exon sequencing of the gene under investigation using genomic DNA as a template for analysis. This approach,...
8.
Gotte K, Hadaczek P, Coy J, Wirtz H, Riedel F, Neubauer J, et al.
Anticancer Res
. 2000 May;
20(2A):1057-60.
PMID: 10810397
Background: The inactivation of the FHIT gene at 3p14.2 by various mechanisms might be of importance in head and neck squamous cell carcinoma (HNSCC). Most reports are based on DNA...
9.
Gronwald J, Hadaczek P, Storkel S, Holtgreve-Grez H, Rabbitts P, Cremer T, et al.
Cancer Detect Prev
. 1999 Nov;
23(6):479-84.
PMID: 10571658
The production of metastases depends on changes in a large number of genes. It is also connected with the interaction of tumor cells with the environment. It has been reported...
10.
Hadaczek P, Kovatich A, Gronwald J, Lubinski J, Huebner K, McCue P
Hum Pathol
. 1999 Nov;
30(11):1276-83.
PMID: 10571505
Involvement of the 3p14.2 region of chromosome 3 in kidney cancers was suggested 20 years ago, when a reciprocal constitutional translocation, t(3;8)(p14.2;q24), was shown to segregate with bilateral clear cell...