P H Scott
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Explore the profile of P H Scott including associated specialties, affiliations and a list of published articles.
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87
Citations
1041
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Recent Articles
1.
2.
Mauger E, Scott P
Biochem Soc Trans
. 2004 Oct;
32(Pt 6):976-7.
PMID: 15506940
Regulation of protein synthesis is an important aspect of growth control. RNA polymerase (pol) III plays a key role in this process by catalysing production of tRNA and 5 S...
3.
Scott P, Morgan T, Durrant S, Boots R
Anaesth Intensive Care
. 2002 Jun;
30(3):289-94.
PMID: 12075635
Survival of bone marrow transplant recipients requiring mechanical ventilation is poor but improving. This study reports a retrospective audit of all haematopoietic stem cell transplant (HSCT) recipients requiring mechanical ventilation...
4.
Ciarmatori S, Scott P, Sutcliffe J, McLees A, Alzuherri H, Dannenberg J, et al.
Mol Cell Biol
. 2001 Aug;
21(17):5806-14.
PMID: 11486020
The "pocket" proteins pRb, p107, and p130 are a family of negative growth regulators. Previous studies have demonstrated that overexpression of pRb can repress transcription by RNA polymerase (Pol) I....
5.
Brown T, Scott P, Stein T, Winter A, White R
Gene Expr
. 2000 Nov;
9(1-2):15-28.
PMID: 11097422
The level of RNA polymerase (pol) III transcription is tightly linked to the rate of growth; it is low in resting cells and increases following mitogenic stimulation. When mammalian cells...
6.
Sutcliffe J, Brown T, Allison S, Scott P, White R
Mol Cell Biol
. 2000 Nov;
20(24):9192-202.
PMID: 11094071
The retinoblastoma protein (RB) has been shown to suppress RNA polymerase (Pol) III transcription in vivo (R. J. White, D. Trouche, K. Martin, S. P. Jackson, and T. Kouzarides, Nature...
7.
Winter A, Sourvinos G, Allison S, Tosh K, Scott P, Spandidos D, et al.
Proc Natl Acad Sci U S A
. 2000 Nov;
97(23):12619-24.
PMID: 11058163
Most transformed cells display abnormally high levels of RNA polymerase (pol) III transcripts. Although the full significance of this is unclear, it may be fundamental because healthy cells use two...
8.
Scott P, Cairns C, Sutcliffe J, Alzuherri H, McLees A, Winter A, et al.
J Biol Chem
. 2000 Oct;
276(2):1005-14.
PMID: 11024049
Increased rates of RNA polymerase (pol) III transcription constitute a central feature of the mitogenic response, but little is known about the mechanism(s) responsible. We demonstrate that the retinoblastoma protein...
9.
Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation
Krymskaya V, Penn R, Orsini M, Scott P, Plevin R, Walker T, et al.
Am J Physiol
. 1999 Jul;
277(1):L65-78.
PMID: 10409232
Hypertrophy and hyperplasia of airway smooth muscle (ASM) are important pathological features that contribute to airflow obstruction in chronic severe asthma. Despite considerable research effort, the cellular mechanisms that modulate...
10.
Scott P, Lawrence Jr J
J Biol Chem
. 1998 Dec;
273(51):34496-501.
PMID: 9852118
Incubating 3T3-L1 adipocytes with forskolin, which increases intracellular cAMP by activating adenylate cyclase, mimicked rapamycin by attenuating the effect of insulin on stimulating the phosphorylation of four (S/T)P sites in...