P Gerwins
Overview
Explore the profile of P Gerwins including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
767
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0
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Recent Articles
1.
Lennmyr F, Ericsson A, Gerwins P, Akterin S, Ahlstrom H, Terent A
Acta Neurol Scand
. 2004 Aug;
110(3):175-9.
PMID: 15285775
Objectives: To investigate the neuroprotective potential of the Src family kinase (SFK) inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo(3,4-d)pyrimidine (PP2) in transient focal cerebral ischemia in the rat. Material And Methods: Sprague-Dawley rats were...
2.
Lennmyr F, Ericsson A, Gerwins P, Ahlstrom H, Terent A
Acta Neurol Scand
. 2003 Nov;
108(5):339-45.
PMID: 14616304
Objectives: Focal cerebral ischemia activates intracellular signaling pathways including the mitogen-activated protein kinase p38, which may be involved in the process of ischemic brain injury. In this study, the effect...
3.
Lennmyr F, Karlsson S, Gerwins P, Ata K, Terent A
Acta Neurol Scand
. 2002 Dec;
106(6):333-40.
PMID: 12460137
Objectives: Mitogen-activated protein kinases (MAPK) regulate cell survival and differentiation. The aim of the present study is to investigate the activation pattern of different MAPKs [extracellular signal-regulated kinase (ERK), c-jun-N-terminal...
4.
Gerwins P, Skoldenberg E, Claesson-Welsh L
Crit Rev Oncol Hematol
. 2000 Jun;
34(3):185-94.
PMID: 10838264
Angiogenesis, formation of new vessels from pre-existing ones, results from stimulation of endothelial cells, which line the vessel wall. These cells will leave their resting state and start to digest...
5.
Sakata N, Hamelmann E, Siadak A, Terada N, Gerwins P, Aruffo A, et al.
Cell Immunol
. 2000 Jun;
201(2):109-23.
PMID: 10831320
Ligation of CD40 using anti-CD40 or soluble CD40-ligand activates numerous intracellular kinases which transduce signals to the nucleus. The nature whereby these signaling events are coupled to distal functional events...
6.
Sakata N, Kawasome H, Terada N, Gerwins P, Johnson G, Gelfand E
Eur J Immunol
. 1999 Oct;
29(9):2999-3008.
PMID: 10508274
In human B cells, antigen receptor ligation and CD40 ligation are known to activate the extracellular-regulated kinases (ERK) and c-Jun N-terminal kinase (JNK) pathways, which in turn regulate many important...
7.
McLeish K, Knall C, Ward R, Gerwins P, Coxon P, Klein J, et al.
J Leukoc Biol
. 1998 Oct;
64(4):537-45.
PMID: 9766635
The signal transduction pathways activated by tumor necrosis factor alpha (TNF-alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) that lead to priming of polymorphonuclear leukocytes (PMNs) are unknown. The hypotheses that these...
8.
Ishizuka T, Kawasome H, Terada N, Takeda K, Gerwins P, Keller G, et al.
J Immunol
. 1998 Oct;
161(7):3624-30.
PMID: 9759885
Mast cells express the receptor tyrosine kinase kit/stem cell factor receptor (SCFR) which is encoded by the proto-oncogene c-kit. Ligation of SCFR induces its dimerization and activation of its intrinsic...
9.
Widmann C, Gerwins P, Johnson N, Jarpe M, Johnson G
Mol Cell Biol
. 1998 Apr;
18(4):2416-29.
PMID: 9528810
MEK kinase 1 (MEKK1) is a 196-kDa protein that, in response to genotoxic agents, was found to undergo phosphorylation-dependent activation. The expression of kinase-inactive MEKK1 inhibited genotoxin-induced apoptosis. Following activation...
10.
Ishizuka T, Terada N, Gerwins P, Hamelmann E, Oshiba A, Fanger G, et al.
Proc Natl Acad Sci U S A
. 1997 Jun;
94(12):6358-63.
PMID: 9177222
Mast cells synthesize and secrete specific cytokines and chemokines which play an important role in allergic inflammation. Aggregation of the high-affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) in MC/9...