P G Gillespie
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Explore the profile of P G Gillespie including associated specialties, affiliations and a list of published articles.
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28
Citations
1440
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Recent Articles
1.
Gillespie P, Albanesi J, Bahler M, Bement W, Berg J, Burgess D, et al.
J Cell Biol
. 2001 Nov;
155(5):703-4.
PMID: 11724811
We suggest that the vertebrate myosin-I field adopt a common nomenclature system based on the names adopted by the Human Genome Organization (HUGO). At present, the myosin-I nomenclature is very...
2.
Gillespie P, Walker R
Nature
. 2001 Sep;
413(6852):194-202.
PMID: 11557988
Mechanotransduction - a cell's conversion of a mechanical stimulus into an electrical signal - reveals vital features of an organism's environment. From hair cells and skin mechanoreceptors in vertebrates, to...
3.
Dumont R, Lins U, Filoteo A, Penniston J, Kachar B, Gillespie P
J Neurosci
. 2001 Jul;
21(14):5066-78.
PMID: 11438582
Mechanoelectrical transduction channels of hair cells allow for the entry of appreciable amounts of Ca(2+), which regulates adaptation and triggers the mechanical activity of hair bundles. Most Ca(2+) that enters...
4.
Kachar B, Parakkal M, Kurc M, Zhao Y, Gillespie P
Proc Natl Acad Sci U S A
. 2000 Nov;
97(24):13336-41.
PMID: 11087873
Transduction-channel gating by hair cells apparently requires a gating spring, an elastic element that transmits force to the channels. To determine whether the gating spring is the tip link, a...
5.
Gillespie P, Gillespie S, Mercer J, Shah K, Shokat K
J Biol Chem
. 1999 Oct;
274(44):31373-81.
PMID: 10531338
Distinguishing the cellular functions carried out by enzymes of highly similar structure would be simplified by the availability of isozyme-selective inhibitors. To determine roles played by individual members of the...
6.
Garcia J, Yee A, Gillespie P, Corey D
J Neurosci
. 1998 Oct;
18(21):8637-47.
PMID: 9786971
Current evidence suggests that the adaptation motor of mechanoelectrical transduction in vertebrate hair cells is myosin-Ibeta. Previously, confocal and electron microscopy of bullfrog saccular hair cells using an anti-myosin-Ibeta antibody...
7.
Steyger P, Gillespie P, Baird R
J Neurosci
. 1998 Jun;
18(12):4603-15.
PMID: 9614235
Recent studies have suggested that myosin Ibeta mediates the adaptation of mechanoelectrical transduction in vestibular hair cells. An important prediction of this hypothesis is that myosin Ibeta should be found...
8.
Yamoah E, Lumpkin E, Dumont R, Smith P, Hudspeth A, Gillespie P
J Neurosci
. 1998 Feb;
18(2):610-24.
PMID: 9425003
Mechanically sensitive hair cells of the auditory and vestibular systems use Ca2+ to control adaptation of mechanical transduction, to effect frequency tuning, to trigger neurotransmitter release, and to mediate efferent...
9.
10.
Hasson T, Gillespie P, Garcia J, Macdonald R, Zhao Y, Yee A, et al.
J Cell Biol
. 1997 Jun;
137(6):1287-307.
PMID: 9182663
To understand how cells differentially use the dozens of myosin isozymes present in each genome, we examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue...