P F Brust
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Explore the profile of P F Brust including associated specialties, affiliations and a list of published articles.
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13
Citations
596
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Recent Articles
1.
Bell D, Butcher A, Berrow N, Page K, Brust P, Nesterova A, et al.
J Neurophysiol
. 2001 Feb;
85(2):816-27.
PMID: 11160515
Voltage-dependent calcium channels (VDCCs) are multimeric complexes composed of a pore-forming alpha(1) subunit together with several accessory subunits, including alpha(2)delta, beta, and, in some cases, gamma subunits. A family of...
2.
Hans M, Urrutia A, Deal C, Brust P, Stauderman K, Ellis S, et al.
Biophys J
. 1999 Feb;
76(3):1384-400.
PMID: 10049321
We have cloned two splice variants of the human homolog of the alpha1A subunit of voltage-gated Ca2+ channels. The sequences of human alpha1A-1 and alpha1A-2 code for proteins of 2510...
3.
Hans M, Luvisetto S, Williams M, Spagnolo M, Urrutia A, Tottene A, et al.
J Neurosci
. 1999 Feb;
19(5):1610-9.
PMID: 10024348
Mutations in alpha1A, the pore-forming subunit of P/Q-type calcium channels, are linked to several human diseases, including familial hemiplegic migraine (FHM). We introduced the four missense mutations linked to FHM...
4.
Williams M, Washburn M, Hans M, Urrutia A, Brust P, Prodanovich P, et al.
J Neurochem
. 1999 Feb;
72(2):791-9.
PMID: 9930755
We have isolated and characterized overlapping cDNAs encoding a novel, voltage-gated Ca2+ channel alpha1 subunit, alpha1H, from a human medullary thyroid carcinoma cell line. The alpha1H subunit is structurally similar...
5.
McCool B, Pin J, Harpold M, Brust P, Stauderman K, Lovinger D
J Neurophysiol
. 1998 Feb;
79(1):379-91.
PMID: 9425207
We have shown previously that metabotropic glutamate receptors with group I-like pharmacology couple to N-type and P/Q-type calcium channels in acutely isolated cortical neurons using G proteins most likely belonging...
6.
McCool B, Harpold M, Stauderman K, Brust P, Lovinger D
Neurosci Lett
. 1998 Feb;
239(2-3):89-92.
PMID: 9469663
The voltage-dependent modulation of neuronal voltage-gated calcium channels by heterotrimeric G protein-coupled receptors potentially provides a means for activity-dependent modulation of synaptic efficacy. Recent attention has focused upon the molecular...
7.
McCool B, Pin J, Brust P, Harpold M, Lovinger D
Mol Pharmacol
. 1996 Oct;
50(4):912-22.
PMID: 8863837
Metabotropic glutamate receptors are G protein-coupled receptors that perform a variety of modulatory roles in the central and peripheral nervous systems. The development of receptor subtype-specific agonists/antagonists has lagged far...
8.
Bleakman D, Bowman D, Bath C, Brust P, Johnson E, Deal C, et al.
Neuropharmacology
. 1995 Jul;
34(7):753-65.
PMID: 8532142
The human alpha 1B-1 alpha 2b beta 1-2 Ca2+ channel was stably expressed in HEK293 cells producing a human brain N-type voltage-dependent calcium channel (VDCC). Whole cell voltage-clamp electrophysiology and...
9.
Williams M, Marubio L, Deal C, Hans M, Brust P, Philipson L, et al.
J Biol Chem
. 1994 Sep;
269(35):22347-57.
PMID: 8071363
We have cloned overlapping cDNAs encoding alpha 1E Ca2+ channel subunits from mouse and human brain. We observed that these alpha 1E transcripts were widely distributed in the central nervous...
10.
Brust P, Simerson S, McCue A, Deal C, Schoonmaker S, Williams M, et al.
Neuropharmacology
. 1993 Nov;
32(11):1089-102.
PMID: 8107964
Voltage-dependent calcium (Ca2+) channels, expressed in the CNS, appear to be multimeric complexes comprised of at least alpha 1, alpha 2 and beta subunits. Previously, we cloned and expressed human...