P E Slagboom
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Explore the profile of P E Slagboom including associated specialties, affiliations and a list of published articles.
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112
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2193
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Recent Articles
1.
Kramer C, Monsegue A, Morwani-Mangnani J, Grootswagers P, Beekman M, Slagboom P, et al.
Mech Ageing Dev
. 2024 Nov;
222:112002.
PMID: 39490538
Background: Exercise and nutrition interventions can slow ageing-induced decline in physiology. However, effects are heterogeneous and usually studied separately per outcome domain. In the VOILA study, we simultaneously study various...
2.
Bogaards F, Gehrmann T, Beekman M, Lakenberg N, Suchiman H, de Groot C, et al.
Nat Commun
. 2024 Aug;
15(1):7013.
PMID: 39147741
Molecular effects of lifestyle interventions are typically studied in a single tissue. Here, we perform a secondary analysis on the sex-specific effects of the Growing Old TOgether trial (GOTO, trial...
3.
Bizzarri D, Reinders M, Beekman M, Slagboom P, van den Akker E
Bioinformatics
. 2022 Jun;
38(15):3847-3849.
PMID: 35695757
Motivation: 1H-NMR metabolomics is rapidly becoming a standard resource in large epidemiological studies to acquire metabolic profiles in large numbers of samples in a relatively low-priced and standardized manner. Concomitantly,...
4.
Bizzarri D, Reinders M, Beekman M, Slagboom P, Bbmri-Nl , van den Akker E
EBioMedicine
. 2021 Dec;
75:103764.
PMID: 34942446
Background: Missing or incomplete phenotypic information can severely deteriorate the statistical power in epidemiological studies. High-throughput quantification of small-molecules in bio-samples, i.e. 'metabolomics', is steadily gaining popularity, as it is...
5.
Kananen L, Enroth L, Raitanen J, Jylhava J, Burkle A, Moreno-Villanueva M, et al.
Sci Rep
. 2021 Mar;
11(1):6139.
PMID: 33731775
Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different populations implies that it is a...
6.
Pelsma I, Claessen K, Slagboom P, Van Heemst D, Pereira A, Kroon H, et al.
Eur J Endocrinol
. 2020 Oct;
184(1):29-39.
PMID: 33112260
Introduction: Pathologically high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in patients with acromegaly are associated with arthropathy. Several studies highlight the potential role of the GH/IGF-1 axis...
7.
Meessen J, Saberi-Hosnijeh F, Bomer N, den Hollander W, van der Bom J, van Hilten J, et al.
Sci Rep
. 2020 Sep;
10(1):15459.
PMID: 32963331
Higher body mass index (BMI) is associated with osteoarthritis (OA) in both weight-bearing and non-weight-bearing joints, suggesting a link between OA and poor metabolic health beyond mechanical loading. This risk...
8.
van der Poort E, Gunn D, Beekman M, Griffiths C, Slagboom P, Van Heemst D, et al.
J Eur Acad Dermatol Venereol
. 2019 Aug;
34(1):97-100.
PMID: 31419349
Background: Onset of basal cell carcinoma (BCC) is connected to skin ageing, but it is unclear whether higher BCC genetic susceptibility drives skin ageing. Objectives: To investigate whether loci increasing...
9.
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
Hagg S, Zhan Y, Karlsson R, Gerritsen L, Ploner A, van der Lee S, et al.
Transl Psychiatry
. 2017 Apr;
7(4):e1100.
PMID: 28418400
The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits,...
10.
Floyd J, Sitlani C, Avery C, Noordam R, Li X, Smith A, et al.
Pharmacogenomics J
. 2016 Dec;
18(1):127-135.
PMID: 27958378
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their effects on QT interval duration and...