P E Mains
Overview
Explore the profile of P E Mains including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
667
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Recent Articles
1.
Piekny A, Mains P
ScientificWorldJournal
. 2004 Feb;
3:1370-81.
PMID: 14755119
We review key morphogenetic events that occur during Caenorhabditis elegans (www.wormbase.org/) embryogenesis. Morphogenesis transforms tissues from one shape into another through cell migrations and shape changes, often utilizing highly conserved...
2.
Piekny A, Wissmann A, Mains P
Genetics
. 2000 Dec;
156(4):1671-89.
PMID: 11102366
let-502 rho-binding kinase and mel-11 myosin phosphatase regulate Caenorhabditis elegans embryonic morphogenesis. Genetic analysis presented here establishes the following modes of let-502 action: (i) loss of only maternal let-502 results...
3.
Srayko M, Buster D, Bazirgan O, McNally F, Mains P
Genes Dev
. 2000 May;
14(9):1072-84.
PMID: 10809666
The Caenorhabditis elegans meiotic spindle is morphologically distinct from the first mitotic spindle, yet both structures form in the same cytoplasm approximately 20 minutes apart. The mei-1 and mei-2 genes...
4.
Wissmann A, Ingles J, Mains P
Dev Biol
. 1999 Apr;
209(1):111-27.
PMID: 10208747
Caenorhabditis elegans embryonic elongation is driven by cell shape changes that cause a contraction of the epidermal cell layer enclosing the embryo. We have previously shown that this process requires...
5.
Ashcroft N, Srayko M, Kosinski M, Mains P, Golden A
Dev Biol
. 1999 Jan;
206(1):15-32.
PMID: 9918692
The CDC25 dual-specificity phosphatase family has been shown to play a key role in cell cycle regulation. The phosphatase activity of CDC25 drives the cell cycle by removing inhibitory phosphates...
6.
Dow M, Mains P
Genetics
. 1998 Sep;
150(1):119-28.
PMID: 9725834
We have previously described the gene mei-1, which encodes an essential component of the Caenorhabditis elegans meiotic spindle. When ectopically expressed after the completion of meiosis, mei-1 protein disrupts the...
7.
Mitenko N, Eisner J, Swiston J, Mains P
Genetics
. 1997 Dec;
147(4):1665-74.
PMID: 9409829
Dominant gain-of-function mutations can give unique insights into the study of gene function. In addition, gain-of-function mutations, unlike loss-of-function alleles, are not biased against the identification of genetically redundant loci....
8.
Wissmann A, Ingles J, McGhee J, Mains P
Genes Dev
. 1997 Feb;
11(4):409-22.
PMID: 9042856
We have identified two genes associated with the hypodermal cell shape changes that occur during elongation of the Caenorhabditis elegans embryo. The first gene, called let-502, encodes a protein with...
9.
Mains P
J Cell Biol
. 1994 Jul;
126(1):199-209.
PMID: 8027178
Genetic evidence suggests that the product of the mei-1 gene of Caenorhabditis elegans is specifically required for meiosis in the female germline. Loss-of-function mei-1 mutations block meiotic spindle formation while...
10.
Mains P
Genetics
. 1994 Feb;
136(2):533-46.
PMID: 8150281
Meiotic spindle formation in the female germline of Caenorhabditis elegans requires expression of the gene mei-1. We have cloned mei-1 by transformation rescue and found that it resides near a...