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P D Kirchhoff

Explore the profile of P D Kirchhoff including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 2
Citations 90
Followers 0
Related Specialty
Biochemistry
Co-Authors
P Taylor
Z Radic
J A McCammon
D M Quinn
S Tara
J M Briggs
A H Elcock
Published In
J Biol Chem
Biopolymers
Affiliations
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Recent Articles
1.
Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge
Tara S, Elcock A, Kirchhoff P, Briggs J, Radic Z, Taylor P, et al.
Biopolymers . 1998 Dec; 46(7):465-74. PMID: 9838872
It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also...
2.
Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin
Radic Z, Kirchhoff P, Quinn D, McCammon J, Taylor P
J Biol Chem . 1997 Sep; 272(37):23265-77. PMID: 9287336
To explore the role that surface and active center charges play in electrostatic attraction of ligands to the active center gorge of acetylcholinesterase (AChE), and the influence of charge on...