P D Kessler
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Explore the profile of P D Kessler including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
874
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0
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Recent Articles
1.
Hatsukami D, Jorenby D, Gonzales D, Rigotti N, Glover E, Oncken C, et al.
Clin Pharmacol Ther
. 2011 Jan;
89(3):392-9.
PMID: 21270788
NicVAX, a nicotine vaccine (3'AmNic-rEPA), has been clinically evaluated to determine whether higher antibody (Ab) concentrations are associated with higher smoking abstinence rates and whether dosages and frequency of administration...
2.
Stewart D, Hilton J, Arnold J, Gregoire J, Rivard A, Archer S, et al.
Gene Ther
. 2006 Jun;
13(21):1503-11.
PMID: 16791287
The demonstration that angiogenic growth factors can stimulate new blood vessel growth and restore perfusion in animal models of myocardial ischemia has led to the development of strategies designed for...
3.
Perrin L, June J, Rosebury W, Robertson A, Kovesdi I, Bruder J, et al.
Gene Ther
. 2004 Mar;
11(6):512-21.
PMID: 14999223
Adenovirus-mediated VEGF gene delivery is being evaluated in clinical trials as a treatment for patients with vascular diseases that stem from ischemia, such as diffuse coronary artery disease and peripheral...
4.
Pauly D, Fraites T, Toma C, Bayes H, Huie M, Hirschhorn R, et al.
Hum Gene Ther
. 2001 Mar;
12(5):527-38.
PMID: 11268285
Pompe disease is a lethal cardioskeletal myopathy in infants and results from genetic deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). Genetic replacement of the cDNA for human GAA (hGAA)...
5.
Kessler P, Byrne B
Annu Rev Physiol
. 1999 Apr;
61:219-42.
PMID: 10099688
This review surveys a wide range of cellular and molecular approaches to strengthening the injured or weakened heart, focusing on strategies to replace dysfunctional, necrotic, or apoptotic cardiomyocytes with new...
6.
Pauly D, Johns D, Matelis L, LAWRENCE J, Byrne B, Kessler P
Gene Ther
. 1998 Jun;
5(4):473-80.
PMID: 9614571
The enzyme acid alpha-glucosidase catalyzes the breakdown of lysosomal glycogen. Absence of this enzyme results in infantile Pompe disease, characterized by hypertrophic cardiomyopathy, skeletal muscle weakness and fatal heart failure...
7.
Inesi G, Lewis D, Sumbilla C, Nandi A, Strock C, Huff K, et al.
Am J Physiol
. 1998 Apr;
274(3):C645-53.
PMID: 9530095
Adenovirus-mediated transfer of cDNA encoding the chicken skeletal muscle sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA1) yielded selective expression in cultured chick embryo cardiac myocytes under control of a segment (-268 base pair)...
8.
Kessler P, Podsakoff G, Chen X, McQuiston S, Colosi P, Matelis L, et al.
Proc Natl Acad Sci U S A
. 1996 Nov;
93(24):14082-7.
PMID: 8943064
Somatic gene therapy has been proposed as a means to achieve systemic delivery of therapeutic proteins. However, there is limited evidence that current methods of gene delivery can practically achieve...
9.
Movement of Ca(2+)-ATPase molecules within the sarcoplasmic/endoplasmic reticulum in skeletal muscle
Kaprielian Z, Robinson S, Fambrough D, Kessler P
J Cell Sci
. 1996 Oct;
109 ( Pt 10):2529-37.
PMID: 8923214
The endoplasmic reticulum undergoes rapid, microscopic changes in its structure, including extension and anastomosis of tubular elements. Such dynamism is expected to manifest itself also as rapid intermixing of membrane...
10.
Robinson S, Cho P, Levitsky H, Olson J, Hruban R, Acker M, et al.
Cell Transplant
. 1996 Jan;
5(1):77-91.
PMID: 8665080
The ability to replace damaged myocardial tissue with new striated muscle would constitute a major advance in the treatment of diseases that irreversibly injure cardiac muscle cells. The creation of...