P D Gershon
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Explore the profile of P D Gershon including associated specialties, affiliations and a list of published articles.
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Recent Articles
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Quiocho F, Hu G, Gershon P
Curr Opin Struct Biol
. 2000 Feb;
10(1):78-86.
PMID: 10679461
Crystal structures have recently become available for two proteins (VP39 and eIF4E) complexed with their cognate ligand - the mRNA cap. Despite their total structural dissimilarity, both proteins bind N7-methylguanine...
13.
Hu G, Gershon P, Hodel A, Quiocho F
Proc Natl Acad Sci U S A
. 1999 Jun;
96(13):7149-54.
PMID: 10377383
We have determined, by high resolution x-ray analysis, 10 structures comprising the mRNA cap-specific methyltransferase VP39 or specific mutants thereof in the presence of methylated nucleobase analogs (N1-methyladenine, N3-methyladenine, N1-methylcytosine,...
14.
Johnson L, Gershon P
Nucleic Acids Res
. 1999 Jun;
27(13):2708-21.
PMID: 10373588
The vaccinia virus-encoded heterodimer responsible for poly(A) tail elongation comprises a polyadenylylation catalytic subunit (VP55) and associated processivity factor (VP39). We show that monomeric VP39's affinity for RNA homopolymers follows...
15.
Deng L, Johnson L, Neveu J, Hardin S, Wang S, Lane W, et al.
J Mol Biol
. 1999 Jan;
285(4):1417-27.
PMID: 9917386
VP39 is a bifunctional mRNA-modifying protein that acts as both an mRNA cap-specific 2'-O-methyltransferase and a processivity factor for VP55, the vaccinia poly(A) polymerase catalytic subunit. Although regions of the...
16.
Hodel A, Gershon P, Quiocho F
Mol Cell
. 1998 Jul;
1(3):443-7.
PMID: 9660928
Sequence-nonspecific binding of RNA, recognition of a 7-methylguanosine 5' mRNA cap, and methylation of a nucleic acid backbone are three crucial and ubiquitous events in eukaryotic nucleic acid processing and...
17.
Gershon P, Shi X, Hodel A
Virology
. 1998 Jul;
246(2):253-65.
PMID: 9657944
Vaccinia protein VP39 has two RNA modifying activities. In monomeric form, it acts as an mRNA cap-specific 2'-O-methyltransferase, specifically modifying the ribose moiety of the first transcribed nucleotide of m7G-capped...
18.
Lockless S, Cheng H, Hodel A, Quiocho F, Gershon P
Biochemistry
. 1998 Jun;
37(23):8564-74.
PMID: 9622508
We have investigated the interaction of VP39, the vaccinia-encoded mRNA cap-specific 2'-O-methyltransferase, with its capped RNA substrate. Two sites on the protein surface, responsible for binding the terminal cap nucleotide...
19.
Kuge H, Brownlee G, Gershon P, Richter J
Nucleic Acids Res
. 1998 Jun;
26(13):3208-14.
PMID: 9628920
In Xenopus oocytes, progesterone stimulates the cytoplasmic polyadenylation and resulting translational activation of c-mos mRNA, which is necessary for the induction of oocyte maturation. Although details of the biochemistry of...
20.
Deng L, Beigelman L, Karpeisky A, Gershon P
J Biol Chem
. 1998 Feb;
272(50):31542-52.
PMID: 9395491
VP55, the vaccinia poly(A) polymerase catalytic subunit, interacts with oligonucleotide primers via two uridylate recognition sites (Deng, L., and Gershon, P. D. (1997) EMBO J. 16, 1103-1113). Here, we show...