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P Cron

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Articles 14
Citations 2016
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Recent Articles
1.
Myles T, Schmidt K, Evans D, Cron P, Hemmings B
Biochem J . 2001 Jun; 357(Pt 1):225-32. PMID: 11415453
Members of the phosphoprotein phosphatase (PPP) family of protein serine/threonine phosphatases, including protein phosphatase (PP)1, PP2A and PP2B, share invariant active-site residues that are critical for catalytic function [Zhuo, Clemens,...
2.
Andjelkovic M, Maira S, Cron P, Parker P, Hemmings B
Mol Cell Biol . 1999 Jun; 19(7):5061-72. PMID: 10373555
Protein kinase B (PKB or Akt), a downstream effector of phosphoinositide 3-kinase (PI 3-kinase), has been implicated in insulin signaling and cell survival. PKB is regulated by phosphorylation on Thr308...
3.
Brodbeck D, Cron P, Hemmings B
J Biol Chem . 1999 Mar; 274(14):9133-6. PMID: 10092583
We have cloned human protein kinase Bgamma (PKBgamma) and found that it contains two regulatory phosphorylation sites, Thr305 and Ser472, which correspond to Thr308 and Ser473 of PKBalpha. Thus it...
4.
MEILI R, Cron P, Hemmings B, Ballmer-Hofer K
Oncogene . 1998 Mar; 16(7):903-7. PMID: 9484781
The middle tumor antigen (middle-T) of mouse polyomavirus is responsible for the transforming potential of this virus. Middle-T has been shown to interact with a variety of cellular proteins known...
5.
Andjelkovic M, Alessi D, Meier R, Fernandez A, Lamb N, Frech M, et al.
J Biol Chem . 1998 Feb; 272(50):31515-24. PMID: 9395488
We have investigated the role of subcellular localization in the regulation of protein kinase B (PKB) activation. The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N...
6.
Meier R, Alessi D, Cron P, Andjelkovic M, Hemmings B
J Biol Chem . 1997 Dec; 272(48):30491-7. PMID: 9374542
Protein kinase B (PKB) is a member of the second messenger-dependent family of serine/threonine kinases that has been implicated in signaling pathways downstream of growth factor receptor tyrosine kinases and...
7.
Alessi D, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, et al.
EMBO J . 1996 Dec; 15(23):6541-51. PMID: 8978681
Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after transfection into 293 cells PKBalpha was activated 20- and 50-fold in...
8.
Zolnierowicz S, Van Hoof C, Andjelkovic N, Cron P, Stevens I, MERLEVEDE W, et al.
Biochem J . 1996 Jul; 317 ( Pt 1):187-94. PMID: 8694763
Two protein phosphatase 2A (PP2A) holoenzymes were isolated from rabbit skeletal muscle containing, in addition to the catalytic and PR65 regulatory subunits, proteins of apparent molecular masses of 61 and...
9.
Andjelkovic M, Jakubowicz T, Cron P, Ming X, Han J, Hemmings B
Proc Natl Acad Sci U S A . 1996 Jun; 93(12):5699-704. PMID: 8650155
Treatment of quiescent Swiss 3T3 fibroblasts with serum, or with the phosphatase inhibitors okadaic acid and vanadate, induced a 2- to 11-fold activation of the serine/ threonine RAC protein kinase...
10.
Millward T, Cron P, Hemmings B
Proc Natl Acad Sci U S A . 1995 May; 92(11):5022-6. PMID: 7761441
Human, Drosophila melanogaster, and Caenorhabditis elegans cDNA clones encoding homologues of a serine(threonine) protein kinase (EC 2.7.1.37) (designated Ndr protein kinase) have been isolated and sequenced. The human and Drosophila...