P A Trimmer
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Explore the profile of P A Trimmer including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Parks J, Smith T, Trimmer P, Bennett Jr J, Parker Jr W
J Neurochem
. 2001 Feb;
76(4):1050-6.
PMID: 11181824
Beta amyloid (Abeta) peptides accumulate in Alzheimer's disease and are neurotoxic possibly through the production of oxygen free radicals. Using brain microdialysis we characterized the ability of Abeta to increase...
2.
Sherer T, Trimmer P, Borland K, Parks J, Bennett Jr J, Tuttle J
Brain Res
. 2001 Feb;
891(1-2):94-105.
PMID: 11164812
Sporadic, non-familial Parkinson's disease is characterized by a 15-30% reduction in complex I activity of the electron transport chain. A pharmacological model of reduced complex I activity was created by...
3.
Khan S, Cassarino D, Abramova N, Keeney P, Borland M, Trimmer P, et al.
Ann Neurol
. 2000 Aug;
48(2):148-55.
PMID: 10939564
Alzheimer's disease (AD) is characterized by the deposition in brain of beta-amyloid (Abeta) peptides, elevated brain caspase-3, and systemic deficiency of cytochrome c oxidase. Although increased Abeta deposition can result...
4.
Sherer T, Trimmer P, Parks J, Tuttle J
Biochim Biophys Acta
. 2000 Apr;
1496(2-3):341-55.
PMID: 10771102
To investigate the role of chronic mitochondrial dysfunction on intracellular calcium signaling, we studied basal and stimulated cytosolic calcium levels in SH-SY5Y cells and a derived cell line devoid of...
5.
Trimmer P, Swerdlow R, Parks J, Keeney P, Bennett Jr J, Miller S, et al.
Exp Neurol
. 2000 Mar;
162(1):37-50.
PMID: 10716887
Diseases linked to defective mitochondrial function are characterized by morphologically abnormal, swollen mitochondria with distorted cristae. Several lines of evidence now suggest that sporadic forms of Parkinson's disease (PD) and...
6.
Swerdlow R, Parks J, Davis 2nd J, Cassarino D, Trimmer P, Currie L, et al.
Ann Neurol
. 1998 Dec;
44(6):873-81.
PMID: 9851431
Recent data suggesting complex I dysfunction in Parkinson's disease (PD) arises from mitochondrial DNA (mtDNA) mutation does not conclusively answer whether the responsible genetic lesion is inherited (primary) or somatic...
7.
Swerdlow R, Parks J, Cassarino D, Trimmer P, Miller S, Maguire D, et al.
Exp Neurol
. 1998 Sep;
153(1):135-42.
PMID: 9743575
Mitochondria are abnormal in persons with amyotrophic lateral sclerosis (ALS) for unknown reasons. We explored whether aberration of mitochondrial DNA (mtDNA) could play a role in this by transferring mitochondrial...
8.
Smith T, Trimmer P, Khan S, Tinklepaugh D, Bennett Jr J
Brain Res
. 1997 Aug;
765(2):189-97.
PMID: 9313891
Sporadic Parkinson's disease (PD) may arise from a defect in complex I of the mitochondrial electron transport chain (ETC), transmitted through mitochondrial DNA mutations. The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of experimental...
9.
Steward O, Trimmer P
J Comp Neurol
. 1997 Mar;
380(1):70-81.
PMID: 9073083
This study compares the reactive changes in astrocytes in denervated neuropil regions in normal mice and in mice carrying the Wld(S) mutation which leads to delayed Wallerian degeneration. In situ...
10.
Miller S, Trimmer P, Parker Jr W, Davis R
J Neurochem
. 1996 Nov;
67(5):1897-907.
PMID: 8863494
Mitochondrial dysfunction and attendant bioenergetic defects are increasingly recognized as playing an important role in neurodegenerative disorders. The increased attention on mitochondrial involvement points to the need for developing cell...