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P A Hartz

Explore the profile of P A Hartz including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 103
Followers 0
Related Specialties
Biochemistry
Cell Biology
Biophysics
Top 10 Co-Authors
P D Wilson
L C Racusen
T McMiller
J W BIRD
C R Burrow
B A Fivush
X Zhang
K P Samuel
P W MAJERUS
E Philip
Published In
Cell Biol Int Rep
Biochem Mol Med
Arch Biochem Biophys
J Biol Chem
Kidney Int
Affiliations
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Recent Articles
1.
Low level expression of the HIV-1 Nef protein in transiently transfected COS-1 cells in culture
Hartz P, McMiller T, Scott-Wright D, Samuel K
Cell Mol Biol (Noisy-le-grand) . 2003 Dec; 49(7):1101-7. PMID: 14682392
Nef (negative factor) is a membrane-associated cytoplasmic accessory gene product of HIV-1 that induces increased viral load and pathogenesis in the host. In the present study, we have utilized a...
2.
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate
Zhang X, Hartz P, Philip E, Racusen L, MAJERUS P
J Biol Chem . 1998 Jan; 273(3):1574-82. PMID: 9430698
The protein product of the gene that when mutated is responsible for Lowe syndrome, or oculocerebrorenal syndrome (OCRL), is an inositol polyphosphate 5-phosphatase. It has a marked preference for phosphatidylinositol...
3.
Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion
Hartz P, Wilson P
Biochem Mol Med . 1997 Feb; 60(1):8-26. PMID: 9066978
The phenotype of autosomal dominant polycystic kidney disease (ADPKD) is characterized by basement membrane abnormalities, hyperproliferation, and alterations in epithelial cell polarity. Since proteinases have been implicated in matrix degradation...
4.
Renal proximal tubular epithelium from patients with nephropathic cystinosis: immortalized cell lines as in vitro model systems
Racusen L, Wilson P, Hartz P, Fivush B, Burrow C
Kidney Int . 1995 Aug; 48(2):536-43. PMID: 7564123
The renal proximal tubule is a major site of injury in a variety of congenital/metabolic diseases including nephropathic cystinosis, the most commonly known cause of renal Fanconi's syndrome. In this...
5.
Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases
Wilson P, Hartz P
Cell Biol Int Rep . 1991 Dec; 15(12):1243-58. PMID: 1802407
The mechanisms of toxicity of cyclosporine A (CsA) were studied in primary cultures of individually microdissected rabbit and human renal tubules of proximal and distal regions of the nephron. A...
6.
The question of chymase in cultured muscle cells
Hartz P, BIRD J
Arch Biochem Biophys . 1988 Jun; 263(2):293-8. PMID: 3163910
An alkaline proteinase, identical to mast cell chymase, has been described by a number of laboratories as being associated with myofibrils extracted from adult rat skeletal muscle tissue. A more...