Owen T McCann
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Explore the profile of Owen T McCann including associated specialties, affiliations and a list of published articles.
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9
Citations
4321
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Recent Articles
1.
Ripke S, ODushlaine C, Chambert K, Moran J, Kahler A, Akterin S, et al.
Nat Genet
. 2013 Aug;
45(10):1150-9.
PMID: 23974872
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish...
2.
Sawcer S, Hellenthal G, Pirinen M, Spencer C, Patsopoulos N, Moutsianas L, et al.
Nature
. 2011 Aug;
476(7359):214-9.
PMID: 21833088
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation...
3.
Evans D, Spencer C, Pointon J, Su Z, Harvey D, Kochan G, et al.
Nat Genet
. 2011 Jul;
43(8):761-7.
PMID: 21743469
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report...
4.
Rakyan V, Down T, Maslau S, Andrew T, Yang T, Beyan H, et al.
Genome Res
. 2010 Mar;
20(4):434-9.
PMID: 20219945
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated...
5.
Dubois P, Trynka G, Franke L, Hunt K, Romanos J, Curtotti A, et al.
Nat Genet
. 2010 Mar;
42(4):295-302.
PMID: 20190752
We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs...
6.
Lee J, Lees C, Prescott N, Anderson C, Phillips A, Wesley E, et al.
Nat Genet
. 2009 Nov;
41(12):1330-4.
PMID: 19915572
Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan...
7.
Prokopenko I, Langenberg C, Florez J, Saxena R, Soranzo N, Thorleifsson G, et al.
Nat Genet
. 2008 Dec;
41(1):77-81.
PMID: 19060907
To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European...
8.
Cole C, McCann O, Collins J, Oliver K, Willey D, Gribble S, et al.
Genome Biol
. 2008 May;
9(5):R78.
PMID: 18477386
Background: Although the human genome sequence was declared complete in 2004, the sequence was interrupted by 341 gaps of which 308 lay in an estimated approximately 28 Mb of euchromatin....
9.
Woodfine K, Fiegler H, Beare D, Collins J, McCann O, Young B, et al.
Hum Mol Genet
. 2003 Dec;
13(2):191-202.
PMID: 14645202
We have developed a directly quantitative method utilizing genomic clone DNA microarrays to assess the replication timing of sequences during the S phase of the cell cycle. The genomic resolution...