Owen R Davies
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Explore the profile of Owen R Davies including associated specialties, affiliations and a list of published articles.
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48
Citations
993
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Recent Articles
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Reinke P, Heiringhoff R, Reindl T, Baker K, Taft M, Meents A, et al.
J Biol Chem
. 2024 Oct;
300(12):107925.
PMID: 39461476
Cables formed by head-to-tail polymerization of tropomyosin, localized along the length of sarcomeric and cytoskeletal actin filaments, play a key role in regulating a wide range of motile and contractile...
3.
Dunce J, Davies O
Nat Commun
. 2024 Sep;
15(1):8292.
PMID: 39333100
BRCA2 is essential for DNA repair by homologous recombination in mitosis and meiosis. It interacts with recombinases RAD51 and DMC1 to facilitate the formation of nucleoprotein filaments on resected DNA...
4.
Gurusaran M, Zhang J, Zhang K, Shibuya H, Davies O
Nat Commun
. 2024 Aug;
15(1):6552.
PMID: 39095423
DNA double-strand break repair by homologous recombination has a specialised role in meiosis by generating crossovers that enable the formation of haploid germ cells. This requires meiosis-specific MEILB2-BRME1, which interacts...
5.
Thamkachy R, Medina-Pritchard B, Park S, Chiodi C, Zou J, de la Torre-Barranco M, et al.
EMBO Rep
. 2024 Jul;
25(8):3348-3372.
PMID: 38951710
The centromere, defined by the enrichment of CENP-A (a Histone H3 variant) containing nucleosomes, is a specialised chromosomal locus that acts as a microtubule attachment site. To preserve centromere identity,...
6.
Weber J, Legal T, Lezcano A, Gluszek-Kustusz A, Paterson C, Eibes S, et al.
Curr Biol
. 2024 Feb;
34(5):1133-1141.e4.
PMID: 38354735
The outer corona plays an essential role at the onset of mitosis by expanding to maximize microtubule attachment to kinetochores. The low-density structure of the corona forms through the expansion...
7.
Gurusaran M, Erlandsen B, Davies O
Commun Biol
. 2024 Jan;
7(1):138.
PMID: 38291267
The LINC complex transmits cytoskeletal forces into the nucleus to control the structure and movement of nuclear contents. It is formed of nuclear SUN and cytoplasmic KASH proteins, which interact...
8.
Alexander L, Durairaj J, Kryshtafovych A, Abriata L, Bayo Y, Bhabha G, et al.
Proteins
. 2023 Jul;
91(12):1571-1599.
PMID: 37493353
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how...
9.
Gurusaran M, Biemans J, Wood C, Davies O
Front Cell Dev Biol
. 2023 Jul;
11:1144277.
PMID: 37416798
The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the...
10.
Adams I, Davies O
Annu Rev Genomics Hum Genet
. 2023 May;
24:35-61.
PMID: 37159901
In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein structure, the synaptonemal complex (SC), that assembles between homologous chromosome axes. The mammalian SC comprises at least eight largely...