Owen Laing
Overview
Explore the profile of Owen Laing including associated specialties, affiliations and a list of published articles.
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4
Citations
36
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Recent Articles
1.
Vitillo L, Anjum F, Hewitt Z, Laing O, Ababneh N, Baker D, et al.
Stem Cell Res Ther
. 2025 Feb;
16(1):82.
PMID: 39985055
Background: Cell therapies based on human pluripotent stem cells (hPSCs) are in clinical trials with the aim of restoring vision in people with age-related macular degeneration. The final cell therapy...
2.
Stavish D, Price C, Gelezauskaite G, Alsehli H, Leonhard K, Taapken S, et al.
Stem Cell Reports
. 2024 Jul;
19(8):1217-1232.
PMID: 38964325
Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications in research and clinic. However, the mechanisms that underpin selection of variants remain unclear. Here, through analysis of comprehensive...
3.
Vitillo L, Anjum F, Hewitt Z, Stavish D, Laing O, Baker D, et al.
Stem Cell Reports
. 2023 Feb;
18(3):782-797.
PMID: 36801002
Chromosome 20 abnormalities are some of the most frequent genomic changes acquired by human pluripotent stem cell (hPSC) cultures worldwide. Yet their effects on differentiation remain largely unexplored. We investigated...
4.
Halliwell J, Frith T, Laing O, Price C, Bower O, Stavish D, et al.
Stem Cell Reports
. 2020 May;
14(6):1009-1017.
PMID: 32413278
Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence...
5.
Laing O, Halliwell J, Barbaric I
Curr Protoc Stem Cell Biol
. 2019 Mar;
49(1):e83.
PMID: 30821932
Human pluripotent stem cells (hPSCs) are prone to acquiring genetic changes upon prolonged culture. Particularly common are copy number changes, including gains of chromosomes 1q, 12p, 17q, and 20q, and/or...