Dylan Stavish
Overview
Explore the profile of Dylan Stavish including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
193
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Recent Articles
1.
Stavish D, Price C, Gelezauskaite G, Alsehli H, Leonhard K, Taapken S, et al.
Stem Cell Reports
. 2024 Jul;
19(8):1217-1232.
PMID: 38964325
Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications in research and clinic. However, the mechanisms that underpin selection of variants remain unclear. Here, through analysis of comprehensive...
2.
Saldana-Guerrero I, Montano-Gutierrez L, Boswell K, Hafemeister C, Poon E, Shaw L, et al.
Nat Commun
. 2024 May;
15(1):3745.
PMID: 38702304
Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack...
3.
Cooper F, Souilhol C, Haston S, Gray S, Boswell K, Gogolou A, et al.
Development
. 2024 Jan;
151(3).
PMID: 38223992
The generation of the post-cranial embryonic body relies on the coordinated production of spinal cord neurectoderm and presomitic mesoderm cells from neuromesodermal progenitors (NMPs). This process is orchestrated by pro-neural...
4.
Vitillo L, Anjum F, Hewitt Z, Stavish D, Laing O, Baker D, et al.
Stem Cell Reports
. 2023 Feb;
18(3):782-797.
PMID: 36801002
Chromosome 20 abnormalities are some of the most frequent genomic changes acquired by human pluripotent stem cell (hPSC) cultures worldwide. Yet their effects on differentiation remain largely unexplored. We investigated...
5.
Steventon-Jones V, Stavish D, Halliwell J, Baker D, Barbaric I
Curr Protoc
. 2022 Nov;
2(11):e606.
PMID: 36426882
Human pluripotent stem cells (hPSCs) can be grown in culture indefinitely, making them a valuable tool for use in basic biology, disease modeling, and regenerative medicine. However, over prolonged periods...
6.
Price C, Stavish D, Gokhale P, Stevenson B, Sargeant S, Lacey J, et al.
Dev Cell
. 2021 Aug;
56(17):2455-2470.e10.
PMID: 34407428
The appearance of genetic changes in human pluripotent stem cells (hPSCs) presents a concern for their use in research and regenerative medicine. Variant hPSCs that harbor recurrent culture-acquired aneuploidies display...
7.
Stavish D, Boiers C, Price C, Frith T, Halliwell J, Saldana-Guerrero I, et al.
Nat Commun
. 2020 Oct;
11(1):4989.
PMID: 33020476
We postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias. Using a MIXL1 reporter, we explore mesoderm lineage-bias within the human pluripotent stem cell compartment....
8.
Halliwell J, Frith T, Laing O, Price C, Bower O, Stavish D, et al.
Stem Cell Reports
. 2020 May;
14(6):1009-1017.
PMID: 32413278
Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence...
9.
Frith T, Granata I, Wind M, Stout E, Thompson O, Neumann K, et al.
Elife
. 2018 Aug;
7.
PMID: 30095409
The neural crest (NC) is a multipotent embryonic cell population that generates distinct cell types in an axial position-dependent manner. The production of NC cells from human pluripotent stem cells...
10.
Allison T, Smith A, Anastassiadis K, Sloane-Stanley J, Biga V, Stavish D, et al.
Stem Cell Reports
. 2018 May;
10(6):1895-1907.
PMID: 29779895
Human embryonic stem cells (hESCs) display substantial heterogeneity in gene expression, implying the existence of discrete substates within the stem cell compartment. To determine whether these substates impact fate decisions...