Ouarda Saib
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Explore the profile of Ouarda Saib including associated specialties, affiliations and a list of published articles.
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6
Citations
51
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Recent Articles
1.
de Avila R, Muller I, Barlow H, Middleton A, Theiventhran M, Basili D, et al.
Front Toxicol
. 2025 Mar;
7:1426132.
PMID: 40061084
Introduction: This work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA) framework to assess chemical-induced lung effects using human upper and lower respiratory tract models,...
2.
Cochrane S, Saib O, Sheffield D
Front Toxicol
. 2024 Nov;
6:1462688.
PMID: 39563982
Introduction: As part of a wider programme of work developing next-generation risk assessment approaches (NGRA) using non-animal methods (NAMs) for safety assessment of materials, Unilever SEAC is exploring the use...
3.
Perez-Diaz N, Hoffman E, Clements J, Cruickshank R, Doherty A, Ebner D, et al.
Front Toxicol
. 2023 Jul;
5:1177586.
PMID: 37469456
approaches are an essential tool in screening for toxicity of new chemicals, products and therapeutics. To increase the reproducibility and human relevance of these assessments, it is advocated to remove...
4.
Chen L, Han L, Saib O, Lian G
Pharm Res
. 2014 Nov;
32(5):1779-93.
PMID: 25407547
Purpose: To develop in-silico model for predicting percutaneous absorption and disposition kinetics of chemicals in skin layers so as to facilitate the design of transdermal drug delivery systems and skin...
5.
Maxwell G, MacKay C, Cubberley R, Davies M, Gellatly N, Glavin S, et al.
Toxicol In Vitro
. 2013 Nov;
28(1):8-12.
PMID: 24184331
As documented in the recent OECD report 'the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins' (OECD, 2012), the chemical and biological events driving the induction...
6.
Cappiello A, Famiglini G, Termopoli V, Trufelli H, Zazzeroni R, Jacquoilleot S, et al.
Anal Chem
. 2011 Oct;
83(22):8537-42.
PMID: 21975020
We propose a new analytical approach, based on liquid chromatography (LC) coupled to electron ionization mass spectrometry (EI-MS), using a Direct-EI interface, for dermal absorption evaluation studies. Penetration through the...
7.
Aleksic M, Thain E, Roger D, Saib O, Davies M, Li J, et al.
Toxicol Sci
. 2009 Feb;
108(2):401-11.
PMID: 19221146
The molecular basis of chemical allergy is rooted in the ability of an allergen (hapten) to modify endogenous proteins. This mechanistic understanding aided development of screening assays which generate reproducible...