Ann Doherty
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Explore the profile of Ann Doherty including associated specialties, affiliations and a list of published articles.
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24
Citations
478
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Recent Articles
1.
Marx U, Beken S, Chen Z, Dehne E, Doherty A, Ewart L, et al.
ALTEX
. 2025 Jan;
PMID: 39827406
The regular workshops held by the Center for Alternatives to Animal Testing (CAAT) on biology-inspired microphysiological systems (MPS) taking place every four years, have become a reliable measure to assess...
2.
Zakas P, Cunningham S, Doherty A, van Dijk E, Ibraheim R, Yu S, et al.
Mol Ther
. 2024 Jul;
32(10):3356-3371.
PMID: 38981468
Recombinant adeno-associated virus (rAAV) vector gene delivery systems have demonstrated great promise in clinical trials but continue to face durability and dose-related challenges. Unlike rAAV gene therapy, integrating gene addition...
3.
Shahid F, Doherty A, Wallace E, Schmiedl S, Alexander G, Dreischulte T
Pharmacotherapy
. 2023 Sep;
44(1):87-96.
PMID: 37743815
The strength of evidence for specific ambulatory care prescribing cascades, in which a marker drug is used to treat an adverse event caused by an index drug, has not been...
4.
Stannard L, Doherty A, Chapman K, Doak S, Jenkins G
Mutagenesis
. 2023 Aug;
39(1):13-23.
PMID: 37555614
Cadmium chloride (CdCl2) is a known genotoxic carcinogen, with a mechanism of action thought to partly involve the generation of reactive oxygen species (ROS). We applied here a multi-endpoint approach...
5.
Perez-Diaz N, Hoffman E, Clements J, Cruickshank R, Doherty A, Ebner D, et al.
Front Toxicol
. 2023 Jul;
5:1177586.
PMID: 37469456
approaches are an essential tool in screening for toxicity of new chemicals, products and therapeutics. To increase the reproducibility and human relevance of these assessments, it is advocated to remove...
6.
Hamm G, Maglennon G, Williamson B, Macdonald R, Doherty A, Jones S, et al.
Arch Toxicol
. 2022 Jan;
96(2):613-624.
PMID: 34973110
The receptor tyrosine kinase, MERTK, plays an essential role in homeostasis of the retina via efferocytosis of shed outer nuclear segments of photoreceptors. The Royal College of Surgeons rat model...
7.
David R, Gee S, Khan K, Wilson A, Doherty A
Sci Rep
. 2021 Nov;
11(1):21959.
PMID: 34754012
Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro, reflecting that...
8.
Doherty A, Moriarty F, Boland F, Clyne B, Fahey T, Kennelly S, et al.
HRB Open Res
. 2021 Nov;
4:72.
PMID: 34738069
Internationally, health systems face the challenge of managing a growing ageing population living with multimorbidity and polypharmacy. Potentially inappropriate prescribing is common among patients with polypharmacy, increasing the risk for...
9.
McCoull W, Boyd S, Brown M, Coen M, Collingwood O, Davies N, et al.
J Med Chem
. 2021 Sep;
64(18):13524-13539.
PMID: 34478292
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor...
10.
Wilson A, Grabowski P, Elloway J, Ling S, Stott J, Doherty A
Sci Rep
. 2021 Jan;
11(1):2535.
PMID: 33510380
To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses...