Otor Al-Khalili
Overview
Explore the profile of Otor Al-Khalili including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
328
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0
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Recent Articles
1.
Yue Q, Al-Khalili O, Moseley A, Yoshigi M, Wynne B, Ma H, et al.
Biology (Basel)
. 2022 Dec;
11(12).
PMID: 36552204
We examined the interaction of a membrane-associated protein, MARCKS-like Protein-1 (MLP-1), and an ion channel, Epithelial Sodium Channel (ENaC), with the anionic lipid, phosphatidylinositol 4, 5-phosphate (PIP). We found that...
2.
Wynne B, Samson T, Moyer H, van Elst H, Moseley A, Hecht G, et al.
Am J Physiol Cell Physiol
. 2022 Aug;
323(5):C1512-C1523.
PMID: 35912993
Hypertension is characterized by increased sodium (Na) reabsorption along the aldosterone-sensitive distal nephron (ASDN) as well as chronic systemic inflammation. Interleukin-6 (IL-6) is thought to be a mediator of this...
3.
Song C, Yue Q, Moseley A, Al-Khalili O, Wynne B, Ma H, et al.
Am J Physiol Cell Physiol
. 2020 Jul;
319(3):C589-C604.
PMID: 32639874
The epithelial sodium channel (ENaC) regulates blood pressure by fine-tuning distal nephron sodium reabsorption. Our previous work has shown that ENaC gating is regulated by anionic phospholipid phosphates, including phosphatidylinositol...
4.
Zou L, Linck V, Zhai Y, Galarza-Paez L, Li L, Yue Q, et al.
J Biol Chem
. 2017 Nov;
293(5):1666-1675.
PMID: 29180450
It has been suggested that voltage-dependent anion channels (VDACs) control the release of superoxide from mitochondria. We have previously shown that reactive oxygen species (ROS) such as superoxide (O) and...
5.
Wynne B, Mistry A, Al-Khalili O, Mallick R, Theilig F, Eaton D, et al.
Sci Rep
. 2017 Jun;
7(1):4149.
PMID: 28646163
Distal sodium transport is a final step in the regulation of blood pressure. As such, understanding how the two main sodium transport proteins, the thiazide-sensitive sodium chloride cotransporter (NCC) and...
6.
Montgomery D, Yu L, Ghazi Z, Thai T, Al-Khalili O, Ma H, et al.
Am J Physiol Cell Physiol
. 2017 May;
313(1):C42-C53.
PMID: 28468944
We previously demonstrated a role for the myristoylated alanine-rich C kinase substrate (MARCKS) to serve as an adaptor protein in the anionic phospholipid phosphate-dependent regulation of the epithelial sodium channel...
7.
Trac P, Thai T, Linck V, Zou L, Greenlee M, Yue Q, et al.
Am J Physiol Lung Cell Mol Physiol
. 2017 Mar;
312(6):L797-L811.
PMID: 28283476
A thin fluid layer in alveoli is normal and results from a balance of fluid entry and fluid uptake by transepithelial salt and water reabsorption. Conventional wisdom suggests the reabsorption...
8.
Lucas R, Yue Q, Alli A, Duke B, Al-Khalili O, Thai T, et al.
J Biol Chem
. 2016 Sep;
291(45):23440-23451.
PMID: 27645999
Regulation of the epithelial sodium channel (ENaC), which regulates fluid homeostasis and blood pressure, is complex and remains incompletely understood. The TIP peptide, a mimic of the lectin-like domain of...
9.
Mistry A, Wynne B, Yu L, Tomilin V, Yue Q, Zhou Y, et al.
Biochem J
. 2016 Jul;
473(19):3237-52.
PMID: 27422782
The thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC) are two of the most important determinants of salt balance and thus systemic blood pressure. Abnormalities in either...
10.
Thai T, Yu L, Galarza-Paez L, Wu M, Lam H, Bao H, et al.
J Biol Chem
. 2015 Oct;
290(48):28805-11.
PMID: 26451045
The renal epithelial sodium channel (ENaC) provides regulated sodium transport in the distal nephron. The effects of intracellular calcium ([Ca(2+)]i) on this channel are only beginning to be elucidated. It...