Osvaldo Contreras
Overview
Explore the profile of Osvaldo Contreras including associated specialties, affiliations and a list of published articles.
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26
Citations
566
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Recent Articles
11.
Theret M, Low M, Rempel L, Li F, Tung L, Contreras O, et al.
Life Sci
. 2021 Apr;
279:119482.
PMID: 33891939
Aim: Fibrosis is the most common complication from chronic diseases, and yet no therapy capable of mitigating its effects is available. Our goal is to unveil specific signaling regulating the...
12.
Contreras O, Rossi F, Brandan E
Matrix Biol Plus
. 2021 Feb;
2:100006.
PMID: 33543006
Extracellular matrix (ECM) gives structure, support, and is the niche for several cells found in skeletal muscle. ECM is mainly produced by muscle connective tissue (CT) fibroblasts during development and...
13.
Contreras O, Soliman H, Theret M, Rossi F, Brandan E
J Cell Sci
. 2020 May;
133(12).
PMID: 32434871
Mesenchymal stromal cells (MSCs) are multipotent progenitors essential for organogenesis, tissue homeostasis, regeneration and scar formation. Tissue injury upregulates transforming growth factor β (TGF-β) signaling, which modulates myofibroblast fate, extracellular...
14.
Riquelme-Guzman C, Contreras O
Dev Biol
. 2020 Feb;
461(2):107-109.
PMID: 32035084
The digit tip is an exciting model for studying regeneration in mammals, but the precise mechanisms and the populations of cells involved in the formation and remodeling of the blastema...
15.
Contreras O
J Cell Commun Signal
. 2019 Dec;
14(1):131-133.
PMID: 31865519
Skeletal muscle fibro-adipogenic progenitors (FAPs) are tissue-resident connective tissue cells and the main cellular source of pathological fibro-fatty scar associated with muscle disorders. Although our knowledge about skeletal muscle mesenchymal...
16.
Contreras O, Cruz-Soca M, Theret M, Soliman H, Tung L, Groppa E, et al.
J Cell Sci
. 2019 Aug;
132(19).
PMID: 31434718
Fibro-adipogenic progenitors (FAPs) are tissue-resident mesenchymal stromal cells (MSCs) required for proper skeletal muscle development, regeneration and maintenance. However, FAPs are also responsible for fibro-fatty scar deposition following chronic damage....
17.
Rebolledo D, Gonzalez D, Faundez-Contreras J, Contreras O, Vio C, Murphy-Ullrich J, et al.
Matrix Biol
. 2019 Feb;
82:20-37.
PMID: 30716392
Muscular fibrosis is caused by excessive accumulation of extracellular matrix (ECM) that replaces functional tissue, and it is a feature of several myopathies and neuropathies. Knowledge of the biology and...
18.
Contreras O, Villarreal M, Brandan E
Skelet Muscle
. 2018 Feb;
8(1):5.
PMID: 29463296
Background: Tyrosine kinase inhibitors (TKIs) are effective therapies with demonstrated antineoplastic activity. Nilotinib is a second-generation FDA-approved TKI designed to overcome Imatinib resistance and intolerance in patients with chronic myelogenous...
19.
Riquelme-Guzman C, Contreras O, Brandan E
Am J Physiol Cell Physiol
. 2018 Jan;
314(4):C415-C427.
PMID: 29351412
Fibrosis is a common feature of several chronic diseases and is characterized by exacerbated accumulation of ECM. An understanding of the cellular and molecular mechanisms involved in the development of...
20.
Gonzalez D, Contreras O, Rebolledo D, Espinoza J, van Zundert B, Brandan E
PLoS One
. 2017 May;
12(5):e0177649.
PMID: 28520806
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis and eventually death from respiratory failure. Several studies indicate...