Osamu Tsukamoto
Overview
Explore the profile of Osamu Tsukamoto including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
1561
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Recent Articles
1.
Nishimura S, Kioka H, Ding S, Hakui H, Shinomiya H, Tanabe K, et al.
EMBO Rep
. 2025 Feb;
26(5):1344-1366.
PMID: 39915298
The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through neddylation, the covalent attachment of...
2.
Okamoto C, Tsukamoto O, Hasegawa T, Hitsumoto T, Matsuoka K, Amaki M, et al.
Gastro Hep Adv
. 2024 Aug;
2(2):170-181.
PMID: 39132617
Background And Aims: Recognition of heart failure with preserved ejection fraction (HFpEF) at an early stage in mass screening is desirable, but difficult to achieve. We examined whether the fibrosis...
3.
Tokuyama S, Kato H, Takahashi H, Ueda K, Arita A, Ueda R, et al.
Carcinogenesis
. 2024 Jun;
45(11):857-867.
PMID: 38868979
BRAF V600E, one of the most frequent mutations in the MAPK pathway, confers poor prognosis to colorectal cancers (CRCs), partly because of chemotherapeutic resistance. Oncogene-induced DNA damage responses (DDRs) that...
4.
Okamoto C, Tsukamoto O, Hasegawa T, Matsuoka K, Amaki M, Kanzaki H, et al.
Circ Rep
. 2024 May;
6(5):151-160.
PMID: 38736848
Heart failure patients are deficient in B-type natriuretic peptide (BNP) but the significance of subclinical BNP deficiency is unclear. A total of 1,398 subjects without cardiovascular disease, with left ventricular...
5.
Okamoto C, Tsukamoto O, Hasegawa T, Matsuoka K, Amaki M, Kanzaki H, et al.
JACC Asia
. 2024 Jan;
4(1):87-88.
PMID: 38222257
No abstract available.
6.
Tsukamoto O, Takashima S
Circulation
. 2023 Dec;
148(25):2074-2075.
PMID: 38109341
No abstract available.
7.
Kishimoto H, Iwasaki M, Wada K, Horitani K, Tsukamoto O, Kamikubo K, et al.
iScience
. 2023 Jul;
26(7):107146.
PMID: 37456848
Non-canonical Wnt signaling activated by Wnt5a/Wnt11 is required for the second heart field development in mice. However, the pathophysiological role of non-canonical Wnt signaling in the adult heart has not...
8.
Hitsumoto T, Tsukamoto O, Matsuoka K, Li J, Liu L, Kuramoto Y, et al.
Circulation
. 2023 May;
147(25):1902-1918.
PMID: 37128901
Background: Cardiac-specific myosin light chain kinase (cMLCK), encoded by , regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light chain. However, the pathophysiological and therapeutic implications of cMLCK in...
9.
Oya R, Tsukamoto O, Hitsumoto T, Nakahara N, Okamoto C, Matsuoka K, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163674
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that shows progressive muscle weakness. A few treatments exist including symptomatic therapies, which can prolong survival or reduce a symptom; however, no...
10.
Hakui H, Kioka H, Miyashita Y, Nishimura S, Matsuoka K, Kato H, et al.
Sci Transl Med
. 2022 Jan;
14(628):eabf3274.
PMID: 35044787
Dilated cardiomyopathy (DCM) is a major cause of heart failure, characterized by ventricular dilatation and systolic dysfunction. Familial DCM is reportedly caused by mutations in more than 50 genes, requiring...