Osamu Iwasaki
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Explore the profile of Osamu Iwasaki including associated specialties, affiliations and a list of published articles.
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24
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1346
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Recent Articles
1.
Iwasaki O, Tashiro S, Chung C, Hayashi T, Tanizawa H, Wang X, et al.
bioRxiv
. 2024 Jul;
PMID: 38979137
Eukaryotic genomes are organized by condensin into 3D chromosomal architectures suitable for chromosomal segregation during mitosis. However, molecular mechanisms underlying the condensin-mediated chromosomal organization remain largely unclear. Here, we investigate...
2.
Sakuno T, Tashiro S, Tanizawa H, Iwasaki O, Ding D, Haraguchi T, et al.
Nucleic Acids Res
. 2022 Mar;
50(7):3799-3816.
PMID: 35333350
During meiotic prophase, cohesin-dependent axial structures are formed in the synaptonemal complex (SC). However, the functional correlation between these structures and cohesion remains elusive. Here, we examined the formation of...
3.
Iwasaki O, Tanizawa H, Kim K, Kossenkov A, Nacarelli T, Tashiro S, et al.
Nat Commun
. 2019 Dec;
10(1):5688.
PMID: 31831736
Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations...
4.
Wu S, Fatkhutdinov N, Rosin L, Luppino J, Iwasaki O, Tanizawa H, et al.
Sci Adv
. 2019 May;
5(5):eaaw5294.
PMID: 31131328
ARID1A, a subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex, localizes to both promoters and enhancers to influence transcription. However, the role of ARID1A in higher-order spatial chromosome partitioning and...
5.
Nacarelli T, Lau L, Fukumoto T, Zundell J, Fatkhutdinov N, Wu S, et al.
Nat Cell Biol
. 2019 Feb;
21(3):397-407.
PMID: 30778219
Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated...
6.
Tanizawa H, Kim K, Iwasaki O, Noma K
Nat Struct Mol Biol
. 2017 Oct;
24(11):965-976.
PMID: 28991264
Eukaryotic genomes are highly ordered through various mechanisms, including topologically associating domain (TAD) organization. We employed an in situ Hi-C approach to follow the 3D organization of the fission yeast...
7.
Aird K, Iwasaki O, Kossenkov A, Tanizawa H, Fatkhutdinov N, Bitler B, et al.
J Cell Biol
. 2016 Nov;
215(3):325-334.
PMID: 27799366
Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF). Paradoxically, senescence is also...
8.
Kim K, Tanizawa H, Iwasaki O, Noma K
Nat Genet
. 2016 Aug;
48(10):1242-52.
PMID: 27548313
It is becoming clear that structural-maintenance-of-chromosomes (SMC) complexes such as condensin and cohesin are involved in three-dimensional genome organization, yet their exact roles in functional organization remain unclear. We used...
9.
Iwasaki O, Noma K
Curr Genet
. 2016 Apr;
62(4):739-743.
PMID: 27061734
Genome/chromosome structures are formed by a hierarchy of organizing processes ranging from gene interactions to chromosome territory formation. The SMC complex, cohesin, mediates interactions among enhancers and promoters, thereby regulating...
10.
Iwasaki O, Corcoran C, Noma K
Nucleic Acids Res
. 2015 Dec;
44(8):3618-28.
PMID: 26704981
Chromosomes are not randomly disposed in the nucleus but instead occupy discrete sub-nuclear domains, referred to as chromosome territories. The molecular mechanisms that underlie the formation of chromosome territories and...