Onkar P Kulkarni
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Explore the profile of Onkar P Kulkarni including associated specialties, affiliations and a list of published articles.
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39
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1570
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Recent Articles
1.
Ghosh A, Rayanki N, Joshi A, Kulkarni O
ACS Chem Neurosci
. 2025 Feb;
16(5):908-919.
PMID: 39961731
Kynurenine-3-monooxygenase (KMO), a key enzyme in the kynurenine pathway (KP) of tryptophan metabolism, converts kynurenine into the neurotoxic intermediate quinolinic acid (QA). QA, an -methyl-d-aspartate (NMDA) receptor agonist, increases glutamate...
2.
Nessa S, Lavanya S, Routray R, Chaurasiya A, Kulkarni O, Begum A
Inflammopharmacology
. 2024 Mar;
32(2):1203-1223.
PMID: 38451395
For treating chronic diseases like rheumatoid arthritis, herbal medicines are preferred due to their evident therapeutic effects and lesser side effects as compared to the long-term used conventional drugs. In...
3.
Laxmikeshav K, Rahman Z, Mahale A, Valapil D, Sharma P, George J, et al.
Bioorg Med Chem Lett
. 2023 Oct;
96:129494.
PMID: 37797804
A new class of benzimidazole derivatives as tubulin polymerization inhibitors has been designed and synthesized in this study. The in vitro anticancer profile of the developed molecules was reconnoitred on...
4.
Laxmikeshav K, Sayali M, Devabattula G, Valapil D, Mahale A, Sharma P, et al.
Arch Pharm (Weinheim)
. 2023 Feb;
356(5):e2200449.
PMID: 36807372
A simple "click" protocol was employed in the quest of synthesizing 1,2,3-triazole-linked benzimidazoles as promising anticancer agents on various human cancer cell lines such as A549, HCT116, SK-Mel-28, HT-29, and...
5.
Pulya S, Mahale A, Bobde Y, Routholla G, Patel T, Swati , et al.
ACS Chem Neurosci
. 2021 Feb;
12(5):883-892.
PMID: 33577290
The importance of HDAC3 in transcriptional regulation of genes associated with long-term memory is well established. Here, we report a novel HDAC3 inhibitor, PT3, with an excellent blood-brain barrier permeability...
6.
Begum S, Hira K, Pal P, Nessa S, Kulkarni O, Danaraj J, et al.
Inflammopharmacology
. 2020 Sep;
29(1):253-267.
PMID: 32918703
Objectives: The study aimed to explore the anti-inflammatory effect, underlying mechanism, and chemistry of Halodule pinifolia extract. Methods: The ethyl acetate (EHP) and methanol (MHP) extracts of Halodule pinifolia were...
7.
Kumar S, Hira K, Begum Ahil S, Kulkarni O, Araya H, Fujimoto Y
Inflammopharmacology
. 2020 May;
28(5):1365-1373.
PMID: 32356087
Objectives: The aim of the study was to explore the inhibition efficacy of new synthetic coumarinolignans (SCLs) against the secretion of pro-inflammatory cytokines in two in vivo models of inflammation....
8.
Devarapu S, Kumar Vr S, Rupanagudi K, Kulkarni O, Eulberg D, Klussmann S, et al.
Clin Immunol
. 2017 Nov;
185:119-127.
PMID: 29111236
Induction therapy of proliferative lupus nephritis still requires the use of unselective immunosuppressive drugs with significant toxicities. In search of more specific drugs with equal efficacy but fewer side effects...
9.
Weidenbusch M, Kulkarni O, Anders H
Clin Sci (Lond)
. 2017 Mar;
131(8):625-634.
PMID: 28351959
Although the role of adaptive immune mechanisms, e.g. autoantibody formation and abnormal T-cell activation, has been long noted in the pathogenesis of human systemic lupus erythematosus (SLE), the role of...
10.
Kulkarni O, Lichtnekert J, Anders H, Mulay S
Mediators Inflamm
. 2016 Sep;
2016:2856213.
PMID: 27597803
Inflammation is a response to infections or tissue injuries. Inflammation was once defined by clinical signs, later by the presence of leukocytes, and nowadays by expression of "proinflammatory" cytokines and...