Omkar U Kawalekar
Overview
Explore the profile of Omkar U Kawalekar including associated specialties, affiliations and a list of published articles.
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13
Citations
2768
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Recent Articles
1.
June C, OConnor R, Kawalekar O, Ghassemi S, Milone M
Science
. 2018 Mar;
359(6382):1361-1365.
PMID: 29567707
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from...
2.
Guedan S, Posey Jr A, Shaw C, Wing A, Da T, Patel P, et al.
JCI Insight
. 2018 Jan;
3(1).
PMID: 29321369
Successful tumor eradication by chimeric antigen receptor-expressing (CAR-expressing) T lymphocytes depends on CAR T cell persistence and effector function. We hypothesized that CD4+ and CD8+ T cells may exhibit distinct...
3.
Kawalekar O, O Connor R, Fraietta J, Guo L, McGettigan S, Posey Jr A, et al.
Immunity
. 2017 Aug;
44(3):712.
PMID: 28843072
No abstract available.
4.
Kawalekar O, OConnor R, Fraietta J, Guo L, McGettigan S, Posey Jr A, et al.
Immunity
. 2016 Feb;
44(2):380-90.
PMID: 26885860
Chimeric antigen receptors (CARs) redirect T cell cytotoxicity against cancer cells, providing a promising approach to cancer immunotherapy. Despite extensive clinical use, the attributes of CAR co-stimulatory domains that impact...
5.
Ruella M, Kenderian S, Shestova O, Fraietta J, Qayyum S, Zhang Q, et al.
Clin Cancer Res
. 2016 Jan;
22(11):2684-96.
PMID: 26819453
Purpose: Responses to therapy with chimeric antigen receptor T cells recognizing CD19 (CART19, CTL019) may vary by histology. Mantle cell lymphoma (MCL) represents a B-cell malignancy that remains incurable despite...
6.
Gracias D, Boesteanu A, Fraietta J, Hope J, Carey A, Mueller Y, et al.
J Immunol
. 2016 Jan;
196(3):1186-98.
PMID: 26740110
The p110δ isoform of PI3K is known to play an important role in immunity, yet its contribution to CTL responses has not been fully elucidated. Using murine p110δ-deficient CD8(+) T...
7.
Posey Jr A, Kawalekar O, June C
Curr Protoc Cytom
. 2015 Apr;
72:9.8.1-9.8.21.
PMID: 25827486
Using flow cytometry, single-cell measurements of calcium can be made on isolated populations identified by one or more phenotypic characteristics. Most earlier techniques for measuring cellular activation parameters determined the...
8.
Frigault M, Lee J, Basil M, Carpenito C, Motohashi S, Scholler J, et al.
Cancer Immunol Res
. 2015 Jan;
3(4):356-67.
PMID: 25600436
This study compared second-generation chimeric antigen receptors (CAR) encoding signaling domains composed of CD28, ICOS, and 4-1BB (TNFRSF9). Here, we report that certain CARs endow T cells with the ability...
9.
Muthumani K, Shedlock D, Choo D, Fagone P, Kawalekar O, Goodman J, et al.
J Immunol
. 2011 Aug;
187(6):2932-43.
PMID: 21856939
Recent evidence demonstrates that HIV-1 infection leads to the attenuation of cellular immune responses, which has been correlated with the increased expression of programmed death (PD)-1 on virus-specific CD8(+) T...
10.
Mallilankaraman K, Shedlock D, Bao H, Kawalekar O, Fagone P, Ramanathan A, et al.
PLoS Negl Trop Dis
. 2011 Jan;
5(1):e928.
PMID: 21264351
Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus indigenous to tropical Africa and Asia. Acute illness is characterized by fever, arthralgias, conjunctivitis, rash, and sometimes arthritis. Relatively little is known...