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Omar Arnaout

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Articles 68
Citations 1644
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Recent Articles
1.
McFaline-Figueroa J, Sun L, Youssef G, Huang R, Li G, Kim J, et al.
Nat Commun . 2024 Dec; 15(1):10757. PMID: 39737895
Glioblastoma is immunologically "cold" and resistant to single-agent immune-checkpoint inhibitors (ICI). Our previous study of neoadjuvant pembrolizumab in surgically-accessible recurrent glioblastoma identified a molecular signature of response to ICI and...
2.
Patil A, Serrato P, Chisvo N, Arnaout O, See P, Huang K
Acta Neurochir (Wien) . 2024 Nov; 166(1):475. PMID: 39579215
Background: Large Language Models (LLMs) have garnered increasing attention in neurosurgery and possess significant potential to improve the field. However, the breadth and performance of LLMs across diverse neurosurgical tasks...
3.
Tobochnik S, Regan M, Dorotan M, Reich D, Lapinskas E, Hossain M, et al.
Clin Cancer Res . 2024 Nov; 30(23):5365-5373. PMID: 39499201
Purpose: Glutamatergic neuron-glioma synaptogenesis and peritumoral hyperexcitability promote glioma growth in a positive feedback loop. The objective of this study was to evaluate the feasibility and estimated effect sizes of...
4.
Mehta N, Patel R, Gupta S, Arora H, Nawabi N, Karanth R, et al.
Neurosurgery . 2024 Nov; PMID: 39485023
Background And Objectives: Cerebellopontine angle (CPA) meningiomas present challenges given their proximity to neurovascular structures. Postoperative complications and persistent symptoms can debilitate patients, and our ability to predict recovery course...
5.
Rashid N, Lamba N, Catalano P, Bi W, Arnaout O, Tanguturi S, et al.
Breast Cancer Res Treat . 2024 Oct; 209(2):303-314. PMID: 39367951
Purpose: Neurosurgical resection serves an important role in select patients with breast cancer and brain metastases but can delay systemic therapy and yield complications. Consequently, identification of patients most likely...
6.
Huang K, McNulty J, Hussein H, Klinger N, Chua M, Ng P, et al.
Sci Rep . 2024 Sep; 14(1):22166. PMID: 39333724
While ventricular shunts are the main treatment for adult hydrocephalus, shunt malfunction remains a common problem that can be challenging to diagnose. Computer vision-derived algorithms present a potential solution. We...
7.
Chang C, Chavarro V, Gerstl J, Blitz S, Spanehl L, Dubinski D, et al.
Int J Mol Sci . 2024 Jun; 25(12). PMID: 38928445
Glioblastoma is the most common and lethal central nervous system malignancy with a median survival after progression of only 6-9 months. Major biochemical mechanisms implicated in glioblastoma recurrence include aberrant...
8.
Gerstl J, Gupta S, Stenberg C, Chabros J, Nonnenbroich L, Lindberg R, et al.
Neurosurgery . 2024 Jun; 96(1):205-212. PMID: 38916340
Background And Objectives: Nearly all neurosurgeons in the United States will be named defendants in a malpractice claim before retirement. We perform an assessment of national malpractice trends in cranial...
9.
Tobochnik S, Regan M, Dorotan M, Reich D, Lapinskas E, Hossain M, et al.
medRxiv . 2024 Apr; PMID: 38645003
Background: Glutamatergic neuron-glioma synaptogenesis and peritumoral hyperexcitability promote glioma growth in a positive feedback loop. The objective of this study was to evaluate the feasibility and estimated effect sizes of...
10.
Huang K, Mehta N, Gupta S, See A, Arnaout O
J Clin Neurosci . 2024 Apr; 123:151-156. PMID: 38574687
Background: Although prior work demonstrated the surprising accuracy of Large Language Models (LLMs) on neurosurgery board-style questions, their use in day-to-day clinical situations warrants further investigation. This study assessed GPT-4.0's...