Olivier Lahuna
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Explore the profile of Olivier Lahuna including associated specialties, affiliations and a list of published articles.
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12
Citations
151
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Recent Articles
1.
Ahmad R, Lahuna O, Sidibe A, Daulat A, Zhang Q, Luka M, et al.
Cell Mol Life Sci
. 2020 Jan;
77(24):5189-5205.
PMID: 31900622
Transmission of extracellular signals by G protein-coupled receptors typically relies on a cascade of intracellular events initiated by the activation of heterotrimeric G proteins or β-arrestins followed by effector activation/inhibition....
2.
Bignon Y, Pinelli L, Frachon N, Lahuna O, Figueres L, Houillier P, et al.
Kidney Int
. 2019 Dec;
97(2):304-315.
PMID: 31870500
The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly...
3.
Lahuna O, Jockers R
Biol Aujourdhui
. 2018 Oct;
212(1-2):21-26.
PMID: 30362452
G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with 800 members in humans that are expressed at the cell surface responding to a large panel of...
4.
Bignon Y, Alekov A, Frachon N, Lahuna O, Jean-Baptiste Doh-Egueli C, Deschenes G, et al.
Hum Mutat
. 2018 May;
39(8):1139-1149.
PMID: 29791050
Dent disease is an X-linked recessive renal tubular disorder characterized by low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. Inactivating mutations of CLCN5, the gene encoding the 2Cl /H...
5.
Wojciech S, Ahmad R, Belaid-Choucair Z, Journe A, Gallet S, Dam J, et al.
Nat Commun
. 2018 Mar;
9(1):1216.
PMID: 29572483
Transforming growth factor-β (TGFβ) signaling is initiated by the type I, II TGFβ receptor (TβRI/TβRII) complex. Here we report the formation of an alternative complex between TβRI and the orphan...
6.
Oishi A, Karamitri A, Gerbier R, Lahuna O, Ahmad R, Jockers R
Sci Rep
. 2017 Aug;
7(1):8990.
PMID: 28827538
Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies...
7.
Kellermann G, Kaiser M, Dingli F, Lahuna O, Naud-Martin D, Mahuteau-Betzer F, et al.
Nucleic Acids Res
. 2015 May;
43(15):e99.
PMID: 25958399
Telomerase is the enzyme that maintains the length of telomeres. It is minimally constituted of two components: a core reverse transcriptase protein (hTERT) and an RNA (hTR). Despite its significance...
8.
Keck M, Andrini O, Lahuna O, Burgos J, Cid L, Sepulveda F, et al.
Hum Mutat
. 2013 May;
34(9):1269-78.
PMID: 23703872
Mutations in the CLCNKB gene encoding the ClC-Kb Cl(-) channel cause Bartter syndrome, which is a salt-losing renal tubulopathy. Here, we investigate the functional consequences of seven mutations. When expressed...
9.
Meduri G, Courtillot C, Lahuna O, Kuttenn F, Touraine P, Misrahi M
Med Sci (Paris)
. 2010 Sep;
26(8-9):690-3.
PMID: 20819700
No abstract available.
10.
Achard C, Courtillot C, Lahuna O, Meduri G, Soufir J, Liere P, et al.
N Engl J Med
. 2009 Nov;
361(19):1856-63.
PMID: 19890128
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells. We report a mutation in LHB...