Olga Klezovitch
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Explore the profile of Olga Klezovitch including associated specialties, affiliations and a list of published articles.
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1113
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Recent Articles
1.
Liao S, Rudoy D, Frank S, Phan L, Klezovitch O, Kwan J, et al.
Nat Commun
. 2023 Nov;
14(1):7435.
PMID: 37973913
SND1 and MTDH are known to promote cancer and therapy resistance, but their mechanisms and interactions with other oncogenes remain unclear. Here, we show that oncoprotein ERG interacts with SND1/MTDH...
2.
Bii V, Rudoy D, Klezovitch O, Vasioukhin V
bioRxiv
. 2023 Mar;
PMID: 36945368
Loss of cell polarity and tissue disorganization occurs in majority of epithelial cancers. Studies in simple model organisms identified molecular mechanisms responsible for the establishment and maintenance of cellular polarity,...
3.
Belitskin D, Pant S, Munne P, Suleymanova I, Belitskina K, Hongisto H, et al.
EMBO Rep
. 2021 Sep;
22(11):e52532.
PMID: 34515392
Transforming growth factor-beta (TGFβ) is a multifunctional cytokine with a well-established role in mammary gland development and both oncogenic and tumor-suppressive functions. The extracellular matrix (ECM) indirectly regulates TGFβ activity...
4.
Scott J, Thakar S, Mao Y, Qin H, Hejran H, Lee S, et al.
iScience
. 2019 Sep;
20:25-41.
PMID: 31546104
Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers...
5.
Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien W, et al.
Dev Cell
. 2017 May;
41(5):481-495.e5.
PMID: 28552558
Malformations of the cerebral cortex (MCCs) are devastating developmental disorders. We report here that mice with embryonic neural stem-cell-specific deletion of Llgl1 (Nestin-Cre/Llgl1), a mammalian ortholog of the Drosophila cell...
6.
Beattie R, Postiglione M, Burnett L, Laukoter S, Streicher C, Pauler F, et al.
Neuron
. 2017 May;
94(3):517-533.e3.
PMID: 28472654
The concerted production of neurons and glia by neural stem cells (NSCs) is essential for neural circuit assembly. In the developing cerebral cortex, radial glia progenitors (RGPs) generate nearly all...
7.
Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen C, Ratkovic S, et al.
Genes Dev
. 2017 Jan;
30(24):2696-2709.
PMID: 28087714
Disruption of apical-basal polarity is implicated in developmental disorders and cancer; however, the mechanisms connecting cell polarity proteins with intracellular signaling pathways are largely unknown. We determined previously that membrane-associated...
8.
Klezovitch O, Vasioukhin V
F1000Res
. 2015 Sep;
4(F1000 Faculty Rev):550.
PMID: 26339481
Cadherin-catenin complexes are critical for the assembly of cell-cell adhesion structures known as adherens junctions. In addition to the mechanical linkage of neighboring cells to each other, these cell-cell adhesion...
9.
Nguyen L, Tretiakova M, Silvis M, Lucas J, Klezovitch O, Coleman I, et al.
Cancer Cell
. 2015 Jun;
27(6):797-808.
PMID: 26058078
The significance of ERG in human prostate cancer is unclear because mouse prostate is resistant to ERG-mediated transformation. We determined that ERG activates the transcriptional program regulated by YAP1 of...
10.
Klezovitch O, Vasioukhin V
Dev Cell
. 2013 Oct;
26(6):553-4.
PMID: 24091006
Transcriptional factor Pitx2 is a key regulator of left-right asymmetry in the developing gut. In this issue of Developmental Cell, Welsh et al. (2013) identify the formin Daam2, an effector...