Olaf Klingbeil
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Explore the profile of Olaf Klingbeil including associated specialties, affiliations and a list of published articles.
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18
Citations
492
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Recent Articles
1.
Swamynathan M, Kuang S, Watrud K, Doherty M, Gineste C, Mathew G, et al.
Science
. 2024 Oct;
386(6720):eadk9167.
PMID: 39446948
Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K...
2.
Klingbeil O, Skopelitis D, Tonelli C, Yoshimoto T, Alpsoy A, Panepinto M, et al.
Cancer Discov
. 2024 Jul;
14(12):2471-2488.
PMID: 39058094
The Hippo signaling pathway is commonly dysregulated in human cancer, which leads to a powerful tumor dependency on the YAP/TAZ transcriptional coactivators. In this study, we used paralog cotargeting CRISPR...
3.
He T, Xiao L, Qiao Y, Klingbeil O, Young E, Wu X, et al.
Cancer Cell
. 2024 Jul;
42(8):1336-1351.e9.
PMID: 39029462
The POU2F3-POU2AF2/3 transcription factor complex is the master regulator of the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a specific dependence of the...
4.
He T, Xiao L, Qiao Y, Klingbeil O, Young E, Wu X, et al.
bioRxiv
. 2024 Feb;
PMID: 38328238
The POU2F3-POU2AF2/3 (OCA-T1/2) transcription factor complex is the master regulator of the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we found that the POU2F3 molecular...
5.
Alpsoy A, Wu X, Pal S, Klingbeil O, Kumar P, El Demerdash O, et al.
Mol Cell
. 2024 Feb;
84(6):1149-1157.e7.
PMID: 38309274
OCA-B, OCA-T1, and OCA-T2 belong to a family of coactivators that bind to POU transcription factors (TFs) to regulate gene expression in immune cells. Here, we identify IκBζ (encoded by...
6.
Tonelli C, Yordanov G, Hao Y, Deschenes A, Hinds J, Belleau P, et al.
Gut
. 2024 Jan;
73(6):941-954.
PMID: 38262672
Objective: The optimal therapeutic response in cancer patients is highly dependent upon the differentiation state of their tumours. Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer that harbours distinct phenotypic...
7.
Sun X, Klingbeil O, Lu B, Wu C, Ballon C, OuYang M, et al.
Nature
. 2022 Dec;
613(7942):195-202.
PMID: 36544023
Inhibition of the tumour suppressive function of p53 (encoded by TP53) is paramount for cancer development in humans. However, p53 remains unmutated in the majority of cases of glioblastoma (GBM)-the...
8.
Orstad G, Fort G, Parnell T, Jones A, Stubben C, Lohman B, et al.
Dev Cell
. 2022 Jul;
57(15):1866-1882.e10.
PMID: 35835117
Changes in cellular identity (also known as histologic transformation or lineage plasticity) can drive malignant progression and resistance to therapy in many cancers, including lung adenocarcinoma (LUAD). The lineage-specifying transcription...
9.
Li R, Klingbeil O, Monducci D, Young M, Rodriguez D, Bayyat Z, et al.
Nat Commun
. 2022 May;
13(1):2469.
PMID: 35513429
Combinatorial CRISPR technologies have emerged as a transformative approach to systematically probe genetic interactions and dependencies of redundant gene pairs. However, the performance of different functional genomic tools for multiplexing...
10.
SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Polyanskaya S, Moreno R, Lu B, Feng R, Yao Y, Irani S, et al.
Cell Rep
. 2022 Jan;
38(2):110233.
PMID: 35021089
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we use domain-focused CRISPR screening and identify the nuclear phosphatase SCP4 as a dependency in...