Okko T Pyykko
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Explore the profile of Okko T Pyykko including associated specialties, affiliations and a list of published articles.
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8
Citations
574
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Recent Articles
1.
Bridel C, van Wieringen W, Zetterberg H, Tijms B, Teunissen C, Alvarez-Cermeno J, et al.
JAMA Neurol
. 2019 Jun;
76(9):1035-1048.
PMID: 31206160
Importance: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage....
2.
Pyykko O, Nerg O, Niskasaari H, Niskasaari T, Koivisto A, Hiltunen M, et al.
World Neurosurg
. 2018 Jan;
112:e624-e631.
PMID: 29374607
Object: To investigate the incidence, comorbidities, mortality, and causes of death in idiopathic normal pressure hydrocephalus (iNPH). Methods: A cohort of 536 patients with possible NPH from a defined population...
3.
Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, et al.
J Neurol Sci
. 2016 Aug;
368:11-8.
PMID: 27538594
Idiopathic normal pressure hydrocephalus (iNPH) is a late-onset surgically alleviated, progressive disease. We characterize a potential familial subgroup of iNPH in a nation-wide Finnish cohort of 375 shunt-operated iNPH-patients. The...
4.
Herukka S, Rummukainen J, Ihalainen J, Von Und Zu Fraunberg M, Koivisto A, Nerg O, et al.
J Alzheimers Dis
. 2015 Feb;
46(1):261-9.
PMID: 25720406
Background: Amyloid-β (Aβ1 - 42), total tau (T-tau), and phosphorylated tau (P-tau181) in the cerebrospinal fluid (CSF) are the most promising biomarkers of Alzheimer's disease (AD). Still, little is known...
5.
Pyykko O, Lumela M, Rummukainen J, Nerg O, Seppala T, Herukka S, et al.
PLoS One
. 2014 Mar;
9(3):e91974.
PMID: 24638077
Background: The significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown. Objective: To investigate the role of soluble APP...
6.
Pyykko O, Helisalmi S, Koivisto A, Molsa J, Rummukainen J, Nerg O, et al.
J Neurol Neurosurg Psychiatry
. 2012 Sep;
83(11):1119-24.
PMID: 22955176
Objective: To investigate the association of apolipoprotein E (APOE) genotype, especially the APOE4 allele, to (1) idiopathic normal pressure hydrocephalus (iNPH) and (2) amyloid-β (Aβ) plaques in cortical brain biopsies...
7.
Leinonen V, Koivisto A, Alafuzoff I, Pyykko O, Rummukainen J, Von Und Zu Fraunberg M, et al.
Neurodegener Dis
. 2012 Feb;
10(1-4):166-9.
PMID: 22343771
Normal pressure hydrocephalus (NPH) can be alleviated by cerebrospinal fluid shunting but the differential diagnosis and patient selection are challenging. Intraventricular intracranial pressure monitoring as part of the diagnostic workup...
8.
Leinonen V, Koivisto A, Savolainen S, Rummukainen J, Tamminen J, Tillgren T, et al.
Ann Neurol
. 2010 Oct;
68(4):446-53.
PMID: 20976765
Objective: Amyloid-β(Aβ) aggregates are presumed to be found in the brain at an early stage of Alzheimer's disease (AD) but have seldom been assessed by brain biopsy during life in...