O S Platt
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Explore the profile of O S Platt including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
2423
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Recent Articles
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Chen W, Dumoulin A, Li X, Padovan J, Chait B, Buonopane R, et al.
Biochemistry
. 2000 Mar;
39(13):3774-81.
PMID: 10736177
To correlate amino acid sequence changes with hemoglobin function we are carrying out a detailed recombinant analysis of the adult hemoglobin/fetal hemoglobin (HbA/HbF) systems. The important physiological differences between these...
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Kinney T, HELMS R, Obranski E, Ohene-Frempong K, Wang W, Daeschner C, et al.
Blood
. 1999 Sep;
94(5):1550-4.
PMID: 10477679
Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyurea (HU) therapy in adults with sickle cell anemia. The safety and efficacy of this...
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Kinney T, Sleeper L, Wang W, Zimmerman R, Pegelow C, Ohene-Frempong K, et al.
Pediatrics
. 1999 Mar;
103(3):640-5.
PMID: 10049969
Background: Silent infarcts have been reported in 17% of young patients with sickle cell disease and are associated with impaired performance on standardized psychometric tests. Risk factors for the development...
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Brugnara C, Gee B, Armsby C, Kurth S, Sakamoto M, Rifai N, et al.
J Clin Invest
. 1996 Mar;
97(5):1227-34.
PMID: 8636434
Pathologic water loss from sickle erythrocytes concentrates the abnormal hemoglobin and promotes sickling. The Ca2+-activated K+ channel (Gardos channel) contributes to this deleterious dehydration in vitro, and blockade of K+...
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Platt O, Falcone J
Blood
. 1995 Sep;
86(5):1992-8.
PMID: 7655026
The pattern of membrane abnormalities in sickle red blood cells suggests that sickle hemoglobin damages membrane proteins. We have previously shown a functional defect in sickle ankyrin, poor spectrin-binding ability....
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